Title |
Transcriptional Mechanisms Underlying Sensitization of Peripheral Sensory Neurons by Granulocyte-/Granulocyte-Macrophage Colony Stimulating Factors
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Published in |
Molecular Pain, January 2013
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DOI | 10.1186/1744-8069-9-48 |
Pubmed ID | |
Authors |
Kiran Kumar Bali, Varun Venkataramani, Venkata P Satagopam, Pooja Gupta, Reinhard Schneider, Rohini Kuner |
Abstract |
Cancer-associated pain is a major cause of poor quality of life in cancer patients and is frequently resistant to conventional therapy. Recent studies indicate that some hematopoietic growth factors, namely granulocyte macrophage colony stimulating factor (GMCSF) and granulocyte colony stimulating factor (GCSF), are abundantly released in the tumor microenvironment and play a key role in regulating tumor-nerve interactions and tumor-associated pain by activating receptors on dorsal root ganglion (DRG) neurons. Moreover, these hematopoietic factors have been highly implicated in postsurgical pain, inflammatory pain and osteoarthritic pain. However, the molecular mechanisms via which G-/GMCSF bring about nociceptive sensitization and elicit pain are not known. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Luxembourg | 1 | 3% |
Unknown | 38 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 26% |
Student > Ph. D. Student | 8 | 21% |
Student > Master | 7 | 18% |
Student > Bachelor | 1 | 3% |
Professor | 1 | 3% |
Other | 5 | 13% |
Unknown | 7 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 10 | 26% |
Medicine and Dentistry | 7 | 18% |
Agricultural and Biological Sciences | 5 | 13% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Psychology | 2 | 5% |
Other | 5 | 13% |
Unknown | 8 | 21% |