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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status
|
|---|---|
| Published in |
Microbiome, March 2017
|
| DOI | 10.1186/s40168-017-0252-z |
| Pubmed ID | |
| Authors |
Jôice Dias Corrêa, Débora Cerqueira Calderaro, Gilda Aparecida Ferreira, Santuza Maria Souza Mendonça, Gabriel R. Fernandes, E. Xiao, Antônio Lúcio Teixeira, Eugene J. Leys, Dana T. Graves, Tarcília Aparecida Silva |
| Abstract |
Periodontitis results from the interaction between a subgingival biofilm and host immune response. Changes in biofilm composition are thought to disrupt homeostasis between the host and subgingival bacteria resulting in periodontal damage. Chronic systemic inflammatory disorders have been shown to affect the subgingival microbiota and clinical periodontal status. However, this relationship has not been examined in subjects with systemic lupus erythematosus (SLE). The objective of our study was to investigate the influence of SLE on the subgingival microbiota and its connection with periodontal disease and SLE activity. We evaluated 52 patients with SLE compared to 52 subjects without SLE (control group). Subjects were classified as without periodontitis and with periodontitis. Oral microbiota composition was assessed by amplifying the V4 region of 16S rRNA gene from subgingival dental plaque DNA extracts. These amplicons were examined by Illumina MiSeq sequencing. SLE patients exhibited higher prevalence of periodontitis which occurred at a younger age compared to subjects of the control group. More severe forms of periodontitis were found in SLE subjects that had higher bacterial loads and decreased microbial diversity. Bacterial species frequently detected in periodontal disease were observed in higher proportions in SLE patients, even in periodontal healthy sites such as Fretibacterium, Prevotella nigrescens, and Selenomonas. Changes in the oral microbiota were linked to increased local inflammation, as demonstrated by higher concentrations of IL-6, IL-17, and IL-33 in SLE patients with periodontitis. SLE is associated with differences in the composition of the microbiota, independently of periodontal status. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Latvia | 1 | 17% |
| United States | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Scientists | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Sweden | 1 | <1% |
| Unknown | 155 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 25 | 16% |
| Student > Bachelor | 21 | 13% |
| Student > Ph. D. Student | 16 | 10% |
| Student > Doctoral Student | 16 | 10% |
| Researcher | 12 | 8% |
| Other | 26 | 16% |
| Unknown | 42 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 62 | 39% |
| Agricultural and Biological Sciences | 12 | 8% |
| Immunology and Microbiology | 10 | 6% |
| Biochemistry, Genetics and Molecular Biology | 10 | 6% |
| Sports and Recreations | 3 | 2% |
| Other | 13 | 8% |
| Unknown | 48 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2018.
All research outputs
#2,765,380
of 24,885,505 outputs
Outputs from Microbiome
#1,087
of 1,705 outputs
Outputs of similar age
#50,218
of 314,960 outputs
Outputs of similar age from Microbiome
#28
of 35 outputs
Altmetric has tracked 24,885,505 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,705 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.5. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,960 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.