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Revisiting tumor angiogenesis: vessel co‐option, vessel remodeling, and cancer cell‐derived vasculature formation

Overview of attention for article published in Cancer Communications, January 2016
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Revisiting tumor angiogenesis: vessel co‐option, vessel remodeling, and cancer cell‐derived vasculature formation
Published in
Cancer Communications, January 2016
DOI 10.1186/s40880-015-0070-2
Pubmed ID

Chao-Nan Qian, Min-Han Tan, Jun-Ping Yang, Yun Cao


Tumor growth and metastasis depend on the establishment of tumor vasculature to provide oxygen, nutrients, and other essential factors. The well-known vascular endothelial growth factor (VEGF) signaling is crucial for sprouting angiogenesis as well as recruitment of circulating progenitor endothelial cells to tumor vasculature, which has become therapeutic targets in clinical practice. However, the survival benefits gained from targeting VEGF signaling have been very limited, with the inevitable development of treatment resistance. In this article, we discuss the most recent findings and understanding on how solid tumors evade VEGF-targeted therapy, with a special focus on vessel co-option, vessel remodeling, and tumor cell-derived vasculature establishment. Vessel co-option may occur in tumors independently of sprouting angiogenesis, and sprouting angiogenesis is not always required for tumor growth. The differences between vessel-like structure and tubule-like structure formed by tumor cells are also introduced. The exploration of the underlying mechanisms of these alternative angiogenic approaches would not only widen our knowledge of tumor angiogenesis but also provide novel therapeutic targets for better controlling cancer growth and metastasis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Sweden 1 1%
Unknown 72 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 27%
Researcher 11 15%
Student > Master 11 15%
Student > Bachelor 7 9%
Student > Doctoral Student 5 7%
Other 9 12%
Unknown 11 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 21 28%
Agricultural and Biological Sciences 14 19%
Medicine and Dentistry 12 16%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Immunology and Microbiology 2 3%
Other 10 14%
Unknown 12 16%