Title |
CD146 as an adverse prognostic factor in uterine sarcoma
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Published in |
European Journal of Medical Research, August 2015
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DOI | 10.1186/s40001-015-0160-2 |
Pubmed ID | |
Authors |
Yun Zhou, He Huang, Lin-Jing Yuan, Ying Xiong, Xin Huang, Jia-Xin Lin, Min Zheng |
Abstract |
Uterine sarcoma is an aggressive malignancy with a poor prognosis. This study aimed to determine the expression of CD146, P53, and Ki-67 in uterine sarcoma and to evaluate their prognostic significance. We retrospectively analyzed the prognosis and clinicopathologic features of 68 patients with uterine sarcoma. Immunohistochemical analyses of CD146, P53, and Ki-67 were performed in tissue samples collected from these patients and their relationship with prognosis was investigated. The 5-year overall survival (OS) rate was 46 %. Endometrial stromal sarcoma (ESS) patients had a better prognosis than leiomyosarcoma (LMS) patients, with a 2-year survival rate of 82 %. The membrane and cytoplasm of tumor cells exhibited CD146 overexpression in 8 (32 %) ESS cases, which was less than the 25 (69.4 %) cases observed in LMS and 2 (28.6 %) in MMMT. CD146 overexpression in the membrane and cytoplasm of tumor cells was closely related to lymph node metastasis (P = 0.021) and Ki-67 overexpression (P = 0.0053); there was no significant correlation with age, tumor size, International Federation of Obstetrics and Gynecology stage, or P53 overexpression in LMS. CD146, P53, and Ki-67 are overexpressed in uterine sarcoma. CD146 expression correlates with lymph node metastasis and is associated with poor OS in LMS; it may be a potential prognostic marker for LMS. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 12% |
Other | 3 | 12% |
Student > Bachelor | 3 | 12% |
Student > Master | 3 | 12% |
Professor | 1 | 4% |
Other | 4 | 16% |
Unknown | 8 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 24% |
Agricultural and Biological Sciences | 4 | 16% |
Immunology and Microbiology | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Computer Science | 1 | 4% |
Other | 0 | 0% |
Unknown | 9 | 36% |