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Mendeley readers
| Title |
NK4 therapy: a new approach to target angiogenesis and inflammation in rheumatoid arthritis
|
|---|---|
| Published in |
Arthritis Research & Therapy, September 2013
|
| DOI | 10.1186/ar4320 |
| Pubmed ID | |
| Authors |
Bradley J Rabquer, Alisa E Koch |
| Abstract |
Rheumatoid arthritis (RA) is a progressive autoimmune disease characterized by synovial membrane hyperplasia, inflammation, and angiogenesis. Hepatocyte growth factor (HGF) and its receptor, c-Met, are both overexpressed in the RA synovium. NK4 is an antagonist of HGF which has been shown to inhibit tumor growth, metastasis, and angiogenesis. In an experimental model of RA, NK4 gene therapy inhibited joint damage and inflammation in both preventative and therapeutic models. NK4 treatment therefore represents a possible therapeutic option in combating RA. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 50% |
| Professor > Associate Professor | 1 | 13% |
| Lecturer | 1 | 13% |
| Unknown | 2 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 50% |
| Medicine and Dentistry | 2 | 25% |
| Unknown | 2 | 25% |