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Population-specific association between ABCG2 variants and tophaceous disease in people with gout

Overview of attention for article published in Arthritis Research & Therapy, March 2017
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Title
Population-specific association between ABCG2 variants and tophaceous disease in people with gout
Published in
Arthritis Research & Therapy, March 2017
DOI 10.1186/s13075-017-1254-8
Pubmed ID
Authors

Wendy He, Amanda Phipps-Green, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth

Abstract

Tophi contribute to musculoskeletal disability, joint damage and poor health-related quality of life in people with gout. The aim of this study was to examine the role of SLC2A9 and ABCG2 variants in tophaceous disease in people with gout. Participants (n = 1778) with gout fulfilling the 1977 American Rheumatism Association (ARA) classification criteria, who were recruited from primary and secondary care, attended a detailed study visit. The presence of palpable tophi was recorded. SLC2A9 rs11942223, ABCG2 rs2231142 and ABCG2 rs10011796 were genotyped. Data were analysed according to tophus status. Compared to participants without tophi, those with tophi were older, had longer disease duration and higher serum creatinine, and were more likely to be of Māori or Pacific (Polynesian) ancestry. SLC2A9 rs11942223 was not associated with tophi. However, the risk alleles for both ABCG2 single nucleotide polymorphisms (SNPs) were present more frequently in those with tophi (OR (95% CI) 1.24 (1.02-1.51) for rs2231142 and 1.33 (1.01-1.74) for rs10011796, p < 0.05 for both). The effect of rs2231142 was limited to participants of Māori or Pacific ancestry (OR 1.50 (1.14-1.99), p = 0.004), with a significant effect observed in those of Western Polynesian ancestry only (OR 1.71 (1.07-2.72), p = 0.017). The rs10011796 risk allele was strongly associated with tophi in the Western Polynesian group (OR 3.76 (1.61-8.77), p = 0.002), but not in the Eastern Polynesian group (OR 0.87 (0.52-1.46), p = 0.60) nor in the non-Polynesian group (OR 1.16 (0.81-1.66), p = 0.32). The ABCG2 associations persisted in the Western Polynesian group after adjusting for serum urate, creatinine, and disease duration, and when including both ABCG2 variants in the regression models. Variation in ABCG2 function may play a role in the development of tophaceous disease in some populations with high prevalence of severe gout.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 22%
Student > Ph. D. Student 4 17%
Researcher 3 13%
Student > Doctoral Student 2 9%
Student > Postgraduate 1 4%
Other 0 0%
Unknown 8 35%
Readers by discipline Count As %
Medicine and Dentistry 4 17%
Pharmacology, Toxicology and Pharmaceutical Science 3 13%
Nursing and Health Professions 2 9%
Agricultural and Biological Sciences 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Other 2 9%
Unknown 10 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2017.
All research outputs
#8,931,411
of 11,622,318 outputs
Outputs from Arthritis Research & Therapy
#1,310
of 1,602 outputs
Outputs of similar age
#175,463
of 263,500 outputs
Outputs of similar age from Arthritis Research & Therapy
#2
of 4 outputs
Altmetric has tracked 11,622,318 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,602 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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