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Sulindac activates NF-κB signaling in colon cancer cells

Overview of attention for article published in Cell Communication and Signaling, October 2013
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
24 Dimensions

Readers on

mendeley
22 Mendeley
citeulike
1 CiteULike
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Title
Sulindac activates NF-κB signaling in colon cancer cells
Published in
Cell Communication and Signaling, October 2013
DOI 10.1186/1478-811x-11-73
Pubmed ID
Authors

Dessislava Mladenova, Laurent Pangon, Nicola Currey, Irvin Ng, Elizabeth A Musgrove, Shane T Grey, Maija RJ Kohonen-Corish

Abstract

The non-steroidal anti-inflammatory drug (NSAID) sulindac has shown efficacy in preventing colorectal cancer. This potent anti-tumorigenic effect is mediated through multiple cellular pathways but is also accompanied by gastrointestinal side effects, such as colon inflammation. We have recently shown that sulindac can cause up-regulation of pro-inflammatory factors in the mouse colon mucosa. The aim of this study was to determine the signaling pathways that mediate the transcriptional activation of pro-inflammatory cytokines in colon cancer epithelial cells treated with sulindac sulfide.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 27%
Student > Bachelor 4 18%
Student > Master 3 14%
Student > Doctoral Student 1 5%
Student > Ph. D. Student 1 5%
Other 3 14%
Unknown 4 18%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 5 23%
Biochemistry, Genetics and Molecular Biology 4 18%
Agricultural and Biological Sciences 3 14%
Medicine and Dentistry 3 14%
Immunology and Microbiology 1 5%
Other 0 0%
Unknown 6 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2013.
All research outputs
#5,850,959
of 22,723,682 outputs
Outputs from Cell Communication and Signaling
#120
of 980 outputs
Outputs of similar age
#51,585
of 207,102 outputs
Outputs of similar age from Cell Communication and Signaling
#1
of 9 outputs
Altmetric has tracked 22,723,682 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 980 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,102 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them