Title |
Sulindac activates NF-κB signaling in colon cancer cells
|
---|---|
Published in |
Cell Communication and Signaling, October 2013
|
DOI | 10.1186/1478-811x-11-73 |
Pubmed ID | |
Authors |
Dessislava Mladenova, Laurent Pangon, Nicola Currey, Irvin Ng, Elizabeth A Musgrove, Shane T Grey, Maija RJ Kohonen-Corish |
Abstract |
The non-steroidal anti-inflammatory drug (NSAID) sulindac has shown efficacy in preventing colorectal cancer. This potent anti-tumorigenic effect is mediated through multiple cellular pathways but is also accompanied by gastrointestinal side effects, such as colon inflammation. We have recently shown that sulindac can cause up-regulation of pro-inflammatory factors in the mouse colon mucosa. The aim of this study was to determine the signaling pathways that mediate the transcriptional activation of pro-inflammatory cytokines in colon cancer epithelial cells treated with sulindac sulfide. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 27% |
Student > Bachelor | 4 | 18% |
Student > Master | 3 | 14% |
Student > Doctoral Student | 1 | 5% |
Student > Ph. D. Student | 1 | 5% |
Other | 3 | 14% |
Unknown | 4 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 23% |
Biochemistry, Genetics and Molecular Biology | 4 | 18% |
Agricultural and Biological Sciences | 3 | 14% |
Medicine and Dentistry | 3 | 14% |
Immunology and Microbiology | 1 | 5% |
Other | 0 | 0% |
Unknown | 6 | 27% |