Title |
Quantitative proteomic analysis of amniocytes reveals potentially dysregulated molecular networks in Down syndrome
|
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Published in |
Clinical Proteomics, February 2013
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DOI | 10.1186/1559-0275-10-2 |
Pubmed ID | |
Authors |
Chan-Kyung J Cho, Andrei P Drabovich, George S Karagiannis, Eduardo Martínez-Morillo, Shawn Dason, Apostolos Dimitromanolakis, Eleftherios P Diamandis |
Abstract |
Down syndrome (DS), caused by an extra copy of chromosome 21, affects 1 in 750 live births and is characterized by cognitive impairment and a constellation of congenital defects. Currently, little is known about the molecular pathogenesis and no direct genotype-phenotype relationship has yet been confirmed. Since DS amniocytes are expected to have a distinct biological behaviour compared to normal amniocytes, we hypothesize that relative quantification of proteins produced from trisomy and euploid (chromosomally normal) amniocytes will reveal dysregulated molecular pathways. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 2 | 7% |
Germany | 1 | 4% |
Unknown | 25 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 32% |
Researcher | 8 | 29% |
Student > Doctoral Student | 2 | 7% |
Other | 1 | 4% |
Student > Bachelor | 1 | 4% |
Other | 3 | 11% |
Unknown | 4 | 14% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 29% |
Biochemistry, Genetics and Molecular Biology | 7 | 25% |
Medicine and Dentistry | 5 | 18% |
Unspecified | 1 | 4% |
Neuroscience | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 18% |