Title |
The combined effect of chemoprophylaxis with single dose rifampicin and immunoprophylaxis with BCG to prevent leprosy in contacts of newly diagnosed leprosy cases: a cluster randomized controlled trial (MALTALEP study)
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Published in |
BMC Infectious Diseases, October 2013
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DOI | 10.1186/1471-2334-13-456 |
Pubmed ID | |
Authors |
Renate A Richardus, Khorshed Alam, David Pahan, Sabiena G Feenstra, Annemieke Geluk, Jan H Richardus |
Abstract |
Despite almost 30 years of effective chemotherapy with MDT, the global new case detection rate of leprosy has remained quite constant over the past years. New tools and methodologies are necessary to interrupt the transmission of M. leprae. Single-dose rifampicin (SDR) has been shown to prevent 57% of incident cases of leprosy in the first two years, when given to contacts of newly diagnosed cases. Immunization of contacts with BCG has been less well documented, but appears to have a preventive effect lasting up to 9 years. However, one major disadvantage is the occurrence of excess cases within the first year after immunization. The objective of this study is to examine the effect of chemoprophylaxis with SDR and immunoprophylaxis with BCG on the clinical outcome as well as on host immune responses and gene expression profiles in contacts of newly diagnosed leprosy patients. We hypothesize that the effects of both interventions may be complementary, causing the combined preventive outcome to be significant and long-lasting. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Brazil | 2 | 2% |
Netherlands | 1 | <1% |
Unknown | 119 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 18 | 15% |
Student > Master | 18 | 15% |
Student > Bachelor | 13 | 11% |
Student > Ph. D. Student | 11 | 9% |
Other | 7 | 6% |
Other | 19 | 16% |
Unknown | 36 | 30% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 32 | 26% |
Nursing and Health Professions | 16 | 13% |
Biochemistry, Genetics and Molecular Biology | 8 | 7% |
Social Sciences | 7 | 6% |
Immunology and Microbiology | 7 | 6% |
Other | 15 | 12% |
Unknown | 37 | 30% |