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Thyroid incidentalomas on 18FDG-PET/CT: a metabolico-pathological correlation

Overview of attention for article published in Journal of Otolaryngology - Head & Neck Surgery, March 2017
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Title
Thyroid incidentalomas on 18FDG-PET/CT: a metabolico-pathological correlation
Published in
Journal of Otolaryngology - Head & Neck Surgery, March 2017
DOI 10.1186/s40463-017-0200-8
Pubmed ID
Authors

N. Hagenimana, J. Dallaire, É. Vallée, M. Belzile

Abstract

Thyroid incidentaloma is defined as an unsuspected thyroid lesion found on imaging study or while performing a surgery non-related to the thyroid gland. Most recent scientific literature tends to demonstrate a detection rate of 0.1-4.3% for incidental findings of thyroid focal uptake identified by (18)F-fluorodeoxyglugose Positron Emission Tomography with computed tomography ((18)FDG-PET/CT) initially prescribed for nonthyroid disease. From 10.3 to 80.0% of patients who underwent further evaluation are diagnosed with malignant lesions. Our first objective is to determine the risk of malignancy confined in thyroid incidentalomas(IT) detected on (18)FDG-PET/CT in patients treated in a tertiary care center (Centre Hospitalier Universitaire de Sherbrooke). Second, we want to identify a cut-off value for SUVmax in order to distinguish benign from malignant IT. Third, we look for predictive criterion that can be outlined to help in their management. We retrospectively reviewed 40 914 charts of patients who had a (18)FDG-PET/CT done in a tertiary center from 2004 to 2014. For each patient where a thyroid incidentaloma has been identified, Maximum Standardized Uptake Value (SUVmax), ultrasound report, cytology and histopathological results as well as oncologic outcomes were compiled and analyzed. In this study, the incidence for thyroid incidentaloma detected with (18)FDG-PET/CT is 0.74%. The rate of malignancy present in IT is 8.2% based on histopathological results. Of the patients who underwent surgery, thyroid malignancy was identified in 54.3% of them. Cytoponction showed a strong correlation with final histopathological results (p = 0.009). Thyroid incidentalomas detected with (18)FDG-PET/CT are relatively infrequent, but the potential risk of malignancy remains elevated. Fine needle aspiration biopsy is the investigation of choice to rule out a malignant incidentaloma when there is no other element in the clinical portrait to preclude such additional work up.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 15%
Other 3 11%
Student > Doctoral Student 3 11%
Researcher 3 11%
Student > Postgraduate 2 7%
Other 4 15%
Unknown 8 30%
Readers by discipline Count As %
Medicine and Dentistry 14 52%
Biochemistry, Genetics and Molecular Biology 1 4%
Arts and Humanities 1 4%
Computer Science 1 4%
Nursing and Health Professions 1 4%
Other 0 0%
Unknown 9 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2017.
All research outputs
#22,834,739
of 25,461,852 outputs
Outputs from Journal of Otolaryngology - Head & Neck Surgery
#509
of 629 outputs
Outputs of similar age
#283,671
of 323,169 outputs
Outputs of similar age from Journal of Otolaryngology - Head & Neck Surgery
#14
of 18 outputs
Altmetric has tracked 25,461,852 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 629 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.