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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA
|
|---|---|
| Published in |
Genome Biology, March 2017
|
| DOI | 10.1186/s13059-017-1191-5 |
| Pubmed ID | |
| Authors |
Shuli Kang, Qingjiao Li, Quan Chen, Yonggang Zhou, Stacy Park, Gina Lee, Brandon Grimes, Kostyantyn Krysan, Min Yu, Wei Wang, Frank Alber, Fengzhu Sun, Steven M. Dubinett, Wenyuan Li, Xianghong Jasmine Zhou |
| Abstract |
We propose a probabilistic method, CancerLocator, which exploits the diagnostic potential of cell-free DNA by determining not only the presence but also the location of tumors. CancerLocator simultaneously infers the proportions and the tissue-of-origin of tumor-derived cell-free DNA in a blood sample using genome-wide DNA methylation data. CancerLocator outperforms two established multi-class classification methods on simulations and real data, even with the low proportion of tumor-derived DNA in the cell-free DNA scenarios. CancerLocator also achieves promising results on patient plasma samples with low DNA methylation sequencing coverage. |
X Demographics
The data shown below were collected from the profiles of 149 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 39 | 26% |
| United Kingdom | 18 | 12% |
| Canada | 10 | 7% |
| Spain | 7 | 5% |
| France | 4 | 3% |
| Italy | 3 | 2% |
| Germany | 3 | 2% |
| Australia | 3 | 2% |
| India | 3 | 2% |
| Other | 15 | 10% |
| Unknown | 44 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 85 | 57% |
| Scientists | 52 | 35% |
| Practitioners (doctors, other healthcare professionals) | 7 | 5% |
| Science communicators (journalists, bloggers, editors) | 5 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 447 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Ireland | 1 | <1% |
| United Kingdom | 1 | <1% |
| Sweden | 1 | <1% |
| Argentina | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 440 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 95 | 21% |
| Student > Ph. D. Student | 88 | 20% |
| Student > Master | 36 | 8% |
| Student > Bachelor | 34 | 8% |
| Other | 23 | 5% |
| Other | 54 | 12% |
| Unknown | 117 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 140 | 31% |
| Agricultural and Biological Sciences | 60 | 13% |
| Medicine and Dentistry | 38 | 9% |
| Computer Science | 31 | 7% |
| Engineering | 10 | 2% |
| Other | 36 | 8% |
| Unknown | 132 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 318. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2024.
All research outputs
#108,086
of 25,736,439 outputs
Outputs from Genome Biology
#25
of 4,509 outputs
Outputs of similar age
#2,477
of 323,818 outputs
Outputs of similar age from Genome Biology
#1
of 59 outputs
Altmetric has tracked 25,736,439 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,509 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,818 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.