Comparative analysis of differential network modularity in tissue specific normal and cancer protein interaction networks

Comparative analysis of differential network modularity in tissue specific normal and cancer protein interaction networks

Journal of Clinical Bioinformatics, October 2013

24093757

Md Fahmid Islam, Md Moinul Hoque, Rajat Suvra Banik, Sanjoy Roy, Sharmin Sultana Sumi, F M Nazmul Hassan, Md Tauhid Siddiki Tomal, Ahmad Ullah, K M Taufiqur Rahman

Large scale understanding of complex and dynamic alterations in cellular and subcellular levels during cancer in contrast to normal condition has facilitated the emergence of sophisticated systemic approaches like network biology in recent times. As most biological networks show modular properties, the analysis of differential modularity between normal and cancer protein interaction networks can be a good way to understand cancer more significantly. Two aspects of biological network modularity e.g. detection of molecular complexes (potential modules or clusters) and identification of crucial nodes forming the overlapping modules have been considered in this regard.