Title |
Inhalation of diesel exhaust does not exacerbate cardiac hypertrophy or heart failure in two mouse models of cardiac hypertrophy
|
---|---|
Published in |
Particle and Fibre Toxicology, October 2013
|
DOI | 10.1186/1743-8977-10-49 |
Pubmed ID | |
Authors |
Yonggang Liu, Wei-Ming Chien, Ivan O Medvedev, Chad S Weldy, Daniel L Luchtel, Michael E Rosenfeld, Michael T Chin |
Abstract |
Strong associations have been observed between exposure to fine ambient particulate matter (PM2.5) and adverse cardiovascular outcomes. In particular, exposure to traffic related PM2.5 has been associated with increases in left ventricular hypertrophy, a strong risk factor for cardiovascular mortality. As much of traffic related PM2.5 is derived from diesel exhaust (DE), we investigated the effects of chronic DE exposure on cardiac hypertrophy and heart failure in the adult mouse by exposing mice to DE combined with either of two mouse models of cardiac hypertrophy: angiotensin II infusion or pressure overload induced by transverse aortic banding. |
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