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Abdominal ectopic pregnancy after in vitro fertilization and single embryo transfer: a case report and systematic review

Overview of attention for article published in Reproductive Biology and Endocrinology, October 2016
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Title
Abdominal ectopic pregnancy after in vitro fertilization and single embryo transfer: a case report and systematic review
Published in
Reproductive Biology and Endocrinology, October 2016
DOI 10.1186/s12958-016-0201-x
Pubmed ID
Authors

Nicole Yoder, Reshef Tal, J. Ryan Martin

Abstract

Ectopic pregnancy is the leading cause of maternal morbidity and mortality during the first trimester and the incidence increases dramatically with assisted-reproductive technology (ART), occurring in approximately 1.5-2.1 % of patients undergoing in-vitro fertilization (IVF). Abdominal ectopic pregnancy is a rare yet clinically significant form of ectopic pregnancy due to potentially high maternal morbidity. While risk factors for ectopic pregnancy after IVF have been studied, very little is known about risk factors specific for abdominal ectopic pregnancy. We present a case of a 30 year-old woman who had an abdominal ectopic pregnancy following IVF and elective single embryo transfer, which was diagnosed and managed by laparoscopy. We performed a systematic literature search to identify case reports of abdominal or heterotopic abdominal ectopic pregnancies after IVF. A total of 28 cases were identified. Patients' ages ranged from 23 to 38 (Mean 33.2, S.D. = 3.2). Infertility causes included tubal factor (46 %), endometriosis (14 %), male factor (14 %), pelvic adhesive disease (7 %), structural/DES exposure (7 %), and unexplained infertility (14 %). A history of ectopic pregnancy was identified in 39 % of cases. A history of tubal surgery was identified in 50 % of cases, 32 % cases having had bilateral salpingectomy. Transfer of two embryos or more (79 %) and fresh embryo transfer (71 %) were reported in the majority of cases. Heterotopic abdominal pregnancy occurred in 46 % of cases while 54 % were abdominal ectopic pregnancies. Our systematic review has revealed several trends in reported cases of abdominal ectopic pregnancy after IVF including tubal factor infertility, history of tubal ectopic and tubal surgery, higher number of embryos transferred, and fresh embryo transfers. These are consistent with known risk factors for ectopic pregnancy following IVF. Further research focusing on more homogenous population may help in better characterizing this rare IVF complication and its risks.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 131 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 15%
Student > Master 15 11%
Student > Ph. D. Student 14 11%
Student > Postgraduate 10 8%
Student > Doctoral Student 7 5%
Other 14 11%
Unknown 52 40%
Readers by discipline Count As %
Medicine and Dentistry 53 40%
Nursing and Health Professions 8 6%
Biochemistry, Genetics and Molecular Biology 6 5%
Psychology 3 2%
Computer Science 2 2%
Other 6 5%
Unknown 53 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2023.
All research outputs
#16,545,545
of 24,343,193 outputs
Outputs from Reproductive Biology and Endocrinology
#585
of 1,063 outputs
Outputs of similar age
#204,385
of 320,764 outputs
Outputs of similar age from Reproductive Biology and Endocrinology
#7
of 15 outputs
Altmetric has tracked 24,343,193 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,063 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,764 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.