Title |
Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development
|
---|---|
Published in |
Genome Biology, December 2013
|
DOI | 10.1186/gb-2013-14-10-r108 |
Pubmed ID | |
Authors |
Yi-An Ko, Davoud Mohtat, Masako Suzuki, Ae Seo Deok Park, Maria Concepcion Izquierdo, Sang Youb Han, Hyun Mi Kang, Han Si, Thomas Hostetter, James M Pullman, Melissa Fazzari, Amit Verma, Deyou Zheng, John M Greally, Katalin Susztak |
Abstract |
One in eleven people is affected by chronic kidney disease, a condition characterized by kidney fibrosis and progressive loss of kidney function. Epidemiological studies indicate that adverse intrauterine and postnatal environments have a long-lasting role in chronic kidney disease development. Epigenetic information represents a plausible carrier for mediating this programming effect. Here we demonstrate that genome-wide cytosine methylation patterns of healthy and chronic kidney disease tubule samples obtained from patients show significant differences. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 4 | 36% |
United Kingdom | 2 | 18% |
Unknown | 5 | 45% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 64% |
Scientists | 3 | 27% |
Science communicators (journalists, bloggers, editors) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 2% |
United States | 2 | 2% |
Spain | 1 | <1% |
Unknown | 96 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 26 | 26% |
Researcher | 20 | 20% |
Student > Master | 12 | 12% |
Professor > Associate Professor | 6 | 6% |
Student > Bachelor | 5 | 5% |
Other | 14 | 14% |
Unknown | 18 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 30 | 30% |
Agricultural and Biological Sciences | 23 | 23% |
Biochemistry, Genetics and Molecular Biology | 19 | 19% |
Environmental Science | 2 | 2% |
Economics, Econometrics and Finance | 1 | <1% |
Other | 6 | 6% |
Unknown | 20 | 20% |