Title |
Immune enhancement by novel vaccine adjuvants in autoimmune-prone NZB/W F1 mice: relative efficacy and safety
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Published in |
BMC Immunology, October 2011
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DOI | 10.1186/1471-2172-12-61 |
Pubmed ID | |
Authors |
Youssef Aachoui, Swapan K Ghosh |
Abstract |
Vaccines have profoundly impacted global health although concerns persist about their potential role in autoimmune or other adverse reactions. To address these concerns, vaccine components like immunogens and adjuvants require critical evaluation not only in healthy subjects but also in those genetically averse to vaccine constituents. Evaluation in autoimmune-prone animal models of adjuvants is therefore important in vaccine development. The objective here was to assess the effectiveness of experimental adjuvants: two phytol-derived immunostimulants PHIS-01 (phytanol) and PHIS-03 (phytanyl mannose), and a new commercial adjuvant from porcine small intestinal submucosa (SIS-H), relative to a standard adjuvant alum. Phytol derivatives are hydrophobic, oil-in water diterpenoids, while alum is hydrophilic, and SIS is essentially a biodegradable and collagenous protein cocktail derived from extracellular matrices. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 2 | 22% |
Researcher | 2 | 22% |
Student > Ph. D. Student | 2 | 22% |
Student > Bachelor | 1 | 11% |
Professor | 1 | 11% |
Other | 0 | 0% |
Unknown | 1 | 11% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 22% |
Environmental Science | 1 | 11% |
Veterinary Science and Veterinary Medicine | 1 | 11% |
Immunology and Microbiology | 1 | 11% |
Chemistry | 1 | 11% |
Other | 0 | 0% |
Unknown | 3 | 33% |