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Analytical validation of the Oncotype DX prostate cancer assay – a clinical RT-PCR assay optimized for prostate needle biopsies

Overview of attention for article published in BMC Genomics, October 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

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2 X users
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4 patents
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1 research highlight platform

Citations

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278 Dimensions

Readers on

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223 Mendeley
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Title
Analytical validation of the Oncotype DX prostate cancer assay – a clinical RT-PCR assay optimized for prostate needle biopsies
Published in
BMC Genomics, October 2013
DOI 10.1186/1471-2164-14-690
Pubmed ID
Authors

Dejan Knezevic, Audrey D Goddard, Nisha Natraj, Diana B Cherbavaz, Kim M Clark-Langone, Jay Snable, Drew Watson, Sara M Falzarano, Cristina Magi-Galluzzi, Eric A Klein, Christopher Quale

Abstract

The Oncotype DX Prostate Cancer Assay is a multi-gene RT-PCR expression assay that was developed for use with fixed paraffin-embedded (FPE) diagnostic prostate needle biopsies containing as little as 1 mm of prostate tumor in the greatest dimension. The assay measures expression of 12 cancer-related genes representing four biological pathways and 5 reference genes which are algorithmically combined to calculate the Genomic Prostate Score (GPS). This biopsy-based assay has been analytically and subsequently clinically validated as a predictor of aggressive prostate cancer. The aim of this study was to validate the analytical performance of the Oncotype DX Prostate Cancer Assay using predefined acceptance criteria.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 223 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 3 1%
Korea, Republic of 1 <1%
United Kingdom 1 <1%
India 1 <1%
Belgium 1 <1%
Spain 1 <1%
Unknown 215 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 44 20%
Student > Ph. D. Student 27 12%
Student > Master 24 11%
Other 20 9%
Student > Bachelor 19 9%
Other 51 23%
Unknown 38 17%
Readers by discipline Count As %
Medicine and Dentistry 60 27%
Biochemistry, Genetics and Molecular Biology 35 16%
Agricultural and Biological Sciences 34 15%
Unspecified 8 4%
Engineering 7 3%
Other 24 11%
Unknown 55 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2021.
All research outputs
#4,369,647
of 25,373,627 outputs
Outputs from BMC Genomics
#1,656
of 11,244 outputs
Outputs of similar age
#38,283
of 222,692 outputs
Outputs of similar age from BMC Genomics
#24
of 216 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,244 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,692 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 216 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.