Title |
Overtraining is associated with DNA damage in blood and skeletal muscle cells of Swiss mice
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Published in |
BMC Physiology, October 2013
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DOI | 10.1186/1472-6793-13-11 |
Pubmed ID | |
Authors |
Bruno Cesar Pereira, José Rodrigo Pauli, LusâniaMaria Greggi Antunes, Ellen Cristini de Freitas, Mara Ribeiro de Almeida, Vinícius de Paula Venâncio, Eduardo Rochete Ropelle, Claudio Teodoro de Souza, Dennys Esper Cintra, Marcelo Papoti, AdelinoSanchez Ramos da Silva |
Abstract |
The alkaline version of the single-cell gel (comet) assay is a useful method for quantifying DNA damage. Although some studies on chronic and acute effects of exercise on DNA damage measured by the comet assay have been performed, it is unknown if an aerobic training protocol with intensity, volume, and load clearly defined will improve performance without leading to peripheral blood cell DNA damage. In addition, the effects of overtraining on DNA damage are unknown. Therefore, this study aimed to examine the effects of aerobic training and overtraining on DNA damage in peripheral blood and skeletal muscle cells in Swiss mice. To examine possible changes in these parameters with oxidative stress, we measured reduced glutathione (GSH) levels in total blood, and GSH levels and lipid peroxidation in muscle samples. |
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Netherlands | 1 | 5% |
Japan | 1 | 5% |
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Mendeley readers
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Student > Postgraduate | 8 | 11% |
Student > Doctoral Student | 7 | 10% |
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Unknown | 6 | 8% |
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