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The presence and prognostic impact of apoptotic and nonapoptotic disseminated tumor cells in the bone marrow of primary breast cancer patients after neoadjuvant chemotherapy

Overview of attention for article published in Breast Cancer Research, October 2013
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Title
The presence and prognostic impact of apoptotic and nonapoptotic disseminated tumor cells in the bone marrow of primary breast cancer patients after neoadjuvant chemotherapy
Published in
Breast Cancer Research, October 2013
DOI 10.1186/bcr3496
Pubmed ID
Authors

Andreas Daniel Hartkopf, Florin-Andrei Taran, Markus Wallwiener, Carsten Hagenbeck, Carola Melcher, Natalia Krawczyk, Markus Hahn, Diethelm Wallwiener, Tanja Fehm

Abstract

Neoadjuvant systemic therapy of primary breast cancer (PBC) patients offers the possibility to monitor treatment response. However, patients might have metastatic relapse despite achieving a pathologic complete response (pCR). This indicates that local response to therapy must not be representative for systemic treatment efficacy. Therefore, the aim of this study was to compare local response with systemic tumor cell dissemination by determining the presence of disseminated tumor cells (DTCs), including apoptotic tumor cells, in the bone marrow (BM) of PBC patients after neoadjuvant chemotherapy (NACT).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 26%
Researcher 7 23%
Other 3 10%
Student > Bachelor 3 10%
Lecturer 1 3%
Other 2 6%
Unknown 7 23%
Readers by discipline Count As %
Medicine and Dentistry 12 39%
Agricultural and Biological Sciences 5 16%
Engineering 3 10%
Biochemistry, Genetics and Molecular Biology 1 3%
Sports and Recreations 1 3%
Other 1 3%
Unknown 8 26%