Title |
The presence and prognostic impact of apoptotic and nonapoptotic disseminated tumor cells in the bone marrow of primary breast cancer patients after neoadjuvant chemotherapy
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Published in |
Breast Cancer Research, October 2013
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DOI | 10.1186/bcr3496 |
Pubmed ID | |
Authors |
Andreas Daniel Hartkopf, Florin-Andrei Taran, Markus Wallwiener, Carsten Hagenbeck, Carola Melcher, Natalia Krawczyk, Markus Hahn, Diethelm Wallwiener, Tanja Fehm |
Abstract |
Neoadjuvant systemic therapy of primary breast cancer (PBC) patients offers the possibility to monitor treatment response. However, patients might have metastatic relapse despite achieving a pathologic complete response (pCR). This indicates that local response to therapy must not be representative for systemic treatment efficacy. Therefore, the aim of this study was to compare local response with systemic tumor cell dissemination by determining the presence of disseminated tumor cells (DTCs), including apoptotic tumor cells, in the bone marrow (BM) of PBC patients after neoadjuvant chemotherapy (NACT). |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 23% |
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Unknown | 7 | 23% |
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