Title |
A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancer
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Published in |
BMC Genomics, October 2013
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DOI | 10.1186/1471-2164-14-680 |
Pubmed ID | |
Authors |
Haiyun Wang, Clifford A Meyer, Teng Fei, Gang Wang, Fan Zhang, X Shirley Liu |
Abstract |
The epithelial-to-mesenchymal transition is an important mechanism in cancer metastasis. Although transcription factors including SNAIL, SLUG, and TWIST1 regulate the epithelial-to-mesenchymal transition, other unknown transcription factors could also be involved. Identification of the full complement of transcription factors is essential for a more complete understanding of gene regulation in this process. Chromatin immunoprecipitation-sequencing (ChIP-Seq) technologies have been used to detect genome-wide binding of transcription factors; here, we developed a systematic approach to integrate existing ChIP-Seq and transcriptome data. We scanned multiple transcription factors to investigate their functional impact on the epithelial-to-mesenchymal transition in the human A549 lung adenocarcinoma cell line. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Norway | 1 | 2% |
Unknown | 65 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 20 | 30% |
Student > Master | 10 | 15% |
Researcher | 6 | 9% |
Student > Doctoral Student | 5 | 8% |
Professor | 5 | 8% |
Other | 10 | 15% |
Unknown | 10 | 15% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 22 | 33% |
Agricultural and Biological Sciences | 16 | 24% |
Medicine and Dentistry | 3 | 5% |
Computer Science | 2 | 3% |
Immunology and Microbiology | 2 | 3% |
Other | 7 | 11% |
Unknown | 14 | 21% |