Title |
Feline mammary basal-like adenocarcinomas: a potential model for human triple-negative breast cancer (TNBC) with basal-like subtype
|
---|---|
Published in |
BMC Cancer, September 2013
|
DOI | 10.1186/1471-2407-13-403 |
Pubmed ID | |
Authors |
David A Wiese, Tuddow Thaiwong, Vilma Yuzbasiyan-Gurkan, Matti Kiupel |
Abstract |
Breast cancer is one of the leading causes of cancer deaths. Triple-negative breast cancer (TNBC), an immunophenotype defined by the absence of immunolabeling for estrogen receptor (ER), progesterone receptor (PR) and HER2 protein, has a highly aggressive behavior. A subpopulation of TNBCs exhibit a basal-like morphology with immunohistochemical positivity for cytokeratins 5/6 (CK5/6) and/or epidermal growth factor receptor (EGFR), and have a high incidence of BRCA (breast cancer susceptibility) mutations. Feline mammary adenocarcinomas (FMAs) are highly malignant and share a similar basal-like subtype. The purpose of this study was to classify FMAs according to the current human classification of breast cancer that includes evaluation of ER, PR and HER2 status and expression of basal CK 5/6 and EGFR. Furthermore, we selected triple negative, basal-like FMAs to screen for BRCA mutations similar to those described in human TNBC. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Italy | 1 | 1% |
Unknown | 87 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 15% |
Student > Bachelor | 12 | 13% |
Student > Ph. D. Student | 10 | 11% |
Other | 10 | 11% |
Researcher | 8 | 9% |
Other | 20 | 22% |
Unknown | 16 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 33% |
Veterinary Science and Veterinary Medicine | 24 | 27% |
Biochemistry, Genetics and Molecular Biology | 9 | 10% |
Agricultural and Biological Sciences | 5 | 6% |
Unspecified | 1 | 1% |
Other | 3 | 3% |
Unknown | 18 | 20% |