Title |
Towards the integration, annotation and association of historical microarray experiments with RNA-seq
|
---|---|
Published in |
BMC Bioinformatics, October 2013
|
DOI | 10.1186/1471-2105-14-s14-s4 |
Pubmed ID | |
Authors |
Shweta S Chavan, Michael A Bauer, Erich A Peterson, Christoph J Heuck, Donald J Johann |
Abstract |
Transcriptome analysis by microarrays has produced important advances in biomedicine. For instance in multiple myeloma (MM), microarray approaches led to the development of an effective disease subtyping via cluster assignment, and a 70 gene risk score. Both enabled an improved molecular understanding of MM, and have provided prognostic information for the purposes of clinical management. Many researchers are now transitioning to Next Generation Sequencing (NGS) approaches and RNA-seq in particular, due to its discovery-based nature, improved sensitivity, and dynamic range. Additionally, RNA-seq allows for the analysis of gene isoforms, splice variants, and novel gene fusions. Given the voluminous amounts of historical microarray data, there is now a need to associate and integrate microarray and RNA-seq data via advanced bioinformatic approaches. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 42% |
France | 2 | 17% |
United Kingdom | 1 | 8% |
India | 1 | 8% |
Unknown | 3 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 7 | 58% |
Members of the public | 5 | 42% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 68 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 23% |
Student > Master | 14 | 20% |
Student > Ph. D. Student | 12 | 17% |
Student > Bachelor | 4 | 6% |
Student > Doctoral Student | 3 | 4% |
Other | 12 | 17% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 27 | 39% |
Biochemistry, Genetics and Molecular Biology | 12 | 17% |
Computer Science | 7 | 10% |
Medicine and Dentistry | 7 | 10% |
Mathematics | 1 | 1% |
Other | 5 | 7% |
Unknown | 10 | 14% |