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Micellar liquid chromatographic method for the simultaneous determination of Levofloxacin and Ambroxol in combined tablets: Application to biological fluids

Overview of attention for article published in BMC Chemistry, October 2013
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Title
Micellar liquid chromatographic method for the simultaneous determination of Levofloxacin and Ambroxol in combined tablets: Application to biological fluids
Published in
BMC Chemistry, October 2013
DOI 10.1186/1752-153x-7-162
Pubmed ID
Authors

Fathalla F Belal, Mohie K Sharaf El-Din, Nahed M El-Enany, Samar Saad

Abstract

Levofloxacin hemihydrate (LEV) and ambroxol HCl (AMB) are available for the treatment of upper and lower respiratory tract infections. A survey of the literature reveals that two reversed phase HPLC methods were e reported for the simultaneous determination of LEV and AMB in pharmaceutical preparations. However the reported methods suffers from the low sensitivity, no application of the method in the combined tablets and no application to biological fluids. Also the toxic effects of the used solvents which are harmful to human beings. For this reason, our target was to develop a simple sensitive, less hazardous micellar HPLC method for the simultaneous determination of LEV and AMB in their combined dosage forms and plasma.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 16%
Student > Ph. D. Student 3 16%
Professor 2 11%
Student > Doctoral Student 2 11%
Lecturer 1 5%
Other 2 11%
Unknown 6 32%
Readers by discipline Count As %
Chemistry 7 37%
Nursing and Health Professions 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Earth and Planetary Sciences 1 5%
Economics, Econometrics and Finance 1 5%
Other 0 0%
Unknown 8 42%