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Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

Overview of attention for article published in Genome Biology, March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

news
4 news outlets
blogs
5 blogs
twitter
76 X users
facebook
5 Facebook pages

Citations

dimensions_citation
179 Dimensions

Readers on

mendeley
240 Mendeley
citeulike
2 CiteULike
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Title
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism
Published in
Genome Biology, March 2017
DOI 10.1186/s13059-017-1187-1
Pubmed ID
Authors

Oliver Hahn, Sebastian Grönke, Thomas M. Stubbs, Gabriella Ficz, Oliver Hendrich, Felix Krueger, Simon Andrews, Qifeng Zhang, Michael J. Wakelam, Andreas Beyer, Wolf Reik, Linda Partridge

Abstract

Dietary restriction (DR), a reduction in food intake without malnutrition, increases most aspects of health during aging and extends lifespan in diverse species, including rodents. However, the mechanisms by which DR interacts with the aging process to improve health in old age are poorly understood. DNA methylation could play an important role in mediating the effects of DR because it is sensitive to the effects of nutrition and can affect gene expression memory over time. Here, we profile genome-wide changes in DNA methylation, gene expression and lipidomics in response to DR and aging in female mouse liver. DR is generally strongly protective against age-related changes in DNA methylation. During aging with DR, DNA methylation becomes targeted to gene bodies and is associated with reduced gene expression, particularly of genes involved in lipid metabolism. The lipid profile of the livers of DR mice is correspondingly shifted towards lowered triglyceride content and shorter chain length of triglyceride-associated fatty acids, and these effects become more pronounced with age. Our results indicate that DR remodels genome-wide patterns of DNA methylation so that age-related changes are profoundly delayed, while changes at loci involved in lipid metabolism affect gene expression and the resulting lipid profile.

X Demographics

X Demographics

The data shown below were collected from the profiles of 76 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 240 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
South Africa 1 <1%
Unknown 237 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 45 19%
Student > Ph. D. Student 42 18%
Student > Bachelor 30 13%
Student > Master 28 12%
Student > Doctoral Student 15 6%
Other 27 11%
Unknown 53 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 86 36%
Agricultural and Biological Sciences 43 18%
Medicine and Dentistry 17 7%
Computer Science 6 3%
Neuroscience 6 3%
Other 17 7%
Unknown 65 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 101. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2020.
All research outputs
#425,453
of 25,701,027 outputs
Outputs from Genome Biology
#223
of 4,503 outputs
Outputs of similar age
#8,858
of 323,843 outputs
Outputs of similar age from Genome Biology
#7
of 64 outputs
Altmetric has tracked 25,701,027 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,503 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,843 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.