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Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

Overview of attention for article published in Genome Biology (Online Edition), March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

news
4 news outlets
blogs
5 blogs
twitter
75 tweeters
facebook
5 Facebook pages

Citations

dimensions_citation
141 Dimensions

Readers on

mendeley
218 Mendeley
citeulike
2 CiteULike
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Title
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism
Published in
Genome Biology (Online Edition), March 2017
DOI 10.1186/s13059-017-1187-1
Pubmed ID
Authors

Oliver Hahn, Sebastian Grönke, Thomas M. Stubbs, Gabriella Ficz, Oliver Hendrich, Felix Krueger, Simon Andrews, Qifeng Zhang, Michael J. Wakelam, Andreas Beyer, Wolf Reik, Linda Partridge

Abstract

Dietary restriction (DR), a reduction in food intake without malnutrition, increases most aspects of health during aging and extends lifespan in diverse species, including rodents. However, the mechanisms by which DR interacts with the aging process to improve health in old age are poorly understood. DNA methylation could play an important role in mediating the effects of DR because it is sensitive to the effects of nutrition and can affect gene expression memory over time. Here, we profile genome-wide changes in DNA methylation, gene expression and lipidomics in response to DR and aging in female mouse liver. DR is generally strongly protective against age-related changes in DNA methylation. During aging with DR, DNA methylation becomes targeted to gene bodies and is associated with reduced gene expression, particularly of genes involved in lipid metabolism. The lipid profile of the livers of DR mice is correspondingly shifted towards lowered triglyceride content and shorter chain length of triglyceride-associated fatty acids, and these effects become more pronounced with age. Our results indicate that DR remodels genome-wide patterns of DNA methylation so that age-related changes are profoundly delayed, while changes at loci involved in lipid metabolism affect gene expression and the resulting lipid profile.

Twitter Demographics

The data shown below were collected from the profiles of 75 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 218 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
South Africa 1 <1%
Unknown 215 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 43 20%
Student > Ph. D. Student 42 19%
Student > Bachelor 28 13%
Student > Master 24 11%
Student > Doctoral Student 13 6%
Other 27 12%
Unknown 41 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 80 37%
Agricultural and Biological Sciences 41 19%
Medicine and Dentistry 16 7%
Computer Science 6 3%
Neuroscience 6 3%
Other 16 7%
Unknown 53 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 100. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2020.
All research outputs
#346,407
of 22,479,668 outputs
Outputs from Genome Biology (Online Edition)
#214
of 4,087 outputs
Outputs of similar age
#8,163
of 284,719 outputs
Outputs of similar age from Genome Biology (Online Edition)
#1
of 1 outputs
Altmetric has tracked 22,479,668 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,087 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,719 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them