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Venous endothelial injury in central nervous system diseases

Overview of attention for article published in BMC Medicine, October 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)

Mentioned by

blogs
1 blog
twitter
28 tweeters
facebook
24 Facebook pages
googleplus
1 Google+ user
reddit
1 Redditor

Citations

dimensions_citation
17 Dimensions

Readers on

mendeley
32 Mendeley
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Title
Venous endothelial injury in central nervous system diseases
Published in
BMC Medicine, October 2013
DOI 10.1186/1741-7015-11-219
Pubmed ID
Authors

Jonathan S Alexander, Leonard Prouty, Ikuo Tsunoda, Chaitanya Vijay Ganta, Alireza Minagar

Abstract

The role of the venous system in the pathogenesis of inflammatory neurological/neurodegenerative diseases remains largely unknown and underinvestigated. Aside from cerebral venous infarcts, thromboembolic events, and cerebrovascular bleeding, several inflammatory central nervous system (CNS) diseases, such as multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), and optic neuritis, appear to be associated with venous vascular dysfunction, and the neuropathologic hallmark of these diseases is a perivenous, rather than arterial, lesion. Such findings raise fundamental questions about the nature of these diseases, such as the reasons why their pathognomonic lesions do not develop around the arteries and what exactly are the roles of cerebral venous inflammation in their pathogenesis. Apart from this inflammatory-based view, a new hypothesis with more focus on the hemodynamic features of the cerebral and extracerebral venous system suggests that MS pathophysiology might be associated with the venous system that drains the CNS. Such a hypothesis, if proven correct, opens new therapeutic windows in MS and other neuroinflammatory diseases. Here, we present a comprehensive review of the pathophysiology of MS, ADEM, pseudotumor cerebri, and optic neuritis, with an emphasis on the roles of venous vascular system programming and dysfunction in their pathogenesis. We consider the fundamental differences between arterial and venous endothelium, their dissimilar responses to inflammation, and the potential theoretical contributions of venous insufficiency in the pathogenesis of neurovascular diseases.

Twitter Demographics

The data shown below were collected from the profiles of 28 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 6%
Denmark 1 3%
Brazil 1 3%
Unknown 28 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 22%
Student > Master 4 13%
Professor 3 9%
Student > Ph. D. Student 3 9%
Professor > Associate Professor 3 9%
Other 8 25%
Unknown 4 13%
Readers by discipline Count As %
Medicine and Dentistry 9 28%
Neuroscience 6 19%
Agricultural and Biological Sciences 3 9%
Arts and Humanities 2 6%
Sports and Recreations 2 6%
Other 6 19%
Unknown 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2019.
All research outputs
#1,062,675
of 22,561,331 outputs
Outputs from BMC Medicine
#747
of 3,384 outputs
Outputs of similar age
#9,708
of 189,051 outputs
Outputs of similar age from BMC Medicine
#1
of 1 outputs
Altmetric has tracked 22,561,331 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,384 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.6. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,051 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them