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MiRNA expression in the cartilage of patients with osteoarthritis

Overview of attention for article published in Journal of Orthopaedic Surgery and Research, March 2017
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Title
MiRNA expression in the cartilage of patients with osteoarthritis
Published in
Journal of Orthopaedic Surgery and Research, March 2017
DOI 10.1186/s13018-017-0542-y
Pubmed ID
Authors

Marta Kopańska, Dariusz Szala, Joanna Czech, Natalia Gabło, Krzysztof Gargasz, Mateusz Trzeciak, Izabela Zawlik, Sławomir Snela

Abstract

Osteoarthritis (OA), the most prevalent disease of articulating joints, is a complex multifactorial disease caused by genetic, mechanical, and environmental factors. In this research, we evaluated miRNA expression in OA. Forty tissue samples from 29 patients undergoing joint replacement for OA were evaluated. Tissue from two control patients undergoing hip replacement not related to OA was used as a control. Total RNA (containing miRNA species) from cartilage was isolated using a mirVana miRNA Isolation Kit. Expression of 19 miRNAs was assessed by real-time quantitative polymerase chain reaction. Expression of four miRNAs, miR-138-5p, miR-146a-5p, miR-335-5p, and miR-9-5p, was significantly upregulated in OA tissues (patients vs. control group). These findings may contribute to disease prevention and the development of therapeutic targets for OA.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 15%
Student > Bachelor 6 15%
Researcher 5 12%
Student > Postgraduate 4 10%
Other 3 7%
Other 6 15%
Unknown 11 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 22%
Medicine and Dentistry 6 15%
Agricultural and Biological Sciences 4 10%
Nursing and Health Professions 2 5%
Immunology and Microbiology 2 5%
Other 6 15%
Unknown 12 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2017.
All research outputs
#17,884,576
of 22,961,203 outputs
Outputs from Journal of Orthopaedic Surgery and Research
#916
of 1,394 outputs
Outputs of similar age
#220,318
of 308,511 outputs
Outputs of similar age from Journal of Orthopaedic Surgery and Research
#19
of 44 outputs
Altmetric has tracked 22,961,203 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,394 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 308,511 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.