Title |
Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate
|
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Published in |
Malaria Journal, October 2013
|
DOI | 10.1186/1475-2875-12-359 |
Pubmed ID | |
Authors |
Holly Matthews, Maryam Usman-Idris, Farid Khan, Martin Read, Niroshini Nirmalan |
Abstract |
Drug repurposing or repositioning refers to the usage of existing drugs in diseases other than those it was originally used for. For diseases like malaria, where there is an urgent need for active drug candidates, the strategy offers a route to significantly shorten the traditional drug development pipelines. Preliminary high-throughput screens on patent expired drug libraries have recently been carried out for Plasmodium falciparum. This study reports the systematic and objective further interrogation of selected compounds reported in these studies, to enable their repositioning as novel stand-alone anti-malarials or as combinatorial partners. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 17% |
Netherlands | 1 | 17% |
Myanmar | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 50% |
Members of the public | 2 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 3% |
India | 1 | 1% |
Ghana | 1 | 1% |
Unknown | 69 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 25% |
Researcher | 11 | 15% |
Student > Master | 11 | 15% |
Student > Bachelor | 5 | 7% |
Student > Postgraduate | 4 | 5% |
Other | 12 | 16% |
Unknown | 12 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 12 | 16% |
Agricultural and Biological Sciences | 11 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 12% |
Medicine and Dentistry | 9 | 12% |
Biochemistry, Genetics and Molecular Biology | 8 | 11% |
Other | 9 | 12% |
Unknown | 15 | 21% |