Title |
The ZC3HC1 rs11556924 polymorphism is associated with increased carotid intima-media thickness in patients with rheumatoid arthritis
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Published in |
Arthritis Research & Therapy, October 2013
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DOI | 10.1186/ar4335 |
Pubmed ID | |
Authors |
Raquel López-Mejías, Fernanda Genre, Mercedes García-Bermúdez, Alfonso Corrales, Carlos González-Juanatey, Javier Llorca, José A Miranda-Filloy, Javier Rueda-Gotor, Ricardo Blanco, Santos Castañeda, Javier Martín, Miguel A González-Gay |
Abstract |
Rheumatoid arthritis (RA) is a complex polygenic disease associated with chronic inflammation, accelerated atherosclerosis and increased cardiovascular (CV) mortality. A recent meta-analysis has described the ZC3HC1 rs11556924 polymorphism as one of the most important signals associated with coronary artery disease (CAD) in non-rheumatic Caucasian individuals. In this study we evaluated the potential association of this gene polymorphism with subclinical atherosclerosis assessed by the evaluation of carotid intima-media thickness (cIMT) in RA patients. |
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