Title |
Large-scale polymorphism discovery in macaque G-protein coupled receptors
|
---|---|
Published in |
BMC Genomics, October 2013
|
DOI | 10.1186/1471-2164-14-703 |
Pubmed ID | |
Authors |
Dharmendra B Goswami, Lisa M Ogawa, Joshua M Ward, Gregory M Miller, Eric J Vallender |
Abstract |
G-protein coupled receptors (GPCRs) play an inordinately large role in human health. Variation in the genes that encode these receptors is associated with numerous disorders across the entire spectrum of disease. GPCRs also represent the single largest class of drug targets and associated pharmacogenetic effects are modulated, in part, by polymorphisms. Recently, non-human primate models have been developed focusing on naturally-occurring, functionally-parallel polymorphisms in candidate genes. This work aims to extend those studies broadly across the roughly 377 non-olfactory GPCRs. Initial efforts include resequencing 44 Indian-origin rhesus macaques (Macaca mulatta), 20 Chinese-origin rhesus macaques, and 32 cynomolgus macaques (M. fascicularis). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 4% |
Unknown | 23 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 29% |
Professor > Associate Professor | 4 | 17% |
Student > Bachelor | 2 | 8% |
Other | 2 | 8% |
Student > Ph. D. Student | 2 | 8% |
Other | 3 | 13% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 25% |
Agricultural and Biological Sciences | 5 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Neuroscience | 2 | 8% |
Nursing and Health Professions | 1 | 4% |
Other | 2 | 8% |
Unknown | 6 | 25% |