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Large-scale polymorphism discovery in macaque G-protein coupled receptors

Overview of attention for article published in BMC Genomics, October 2013
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Title
Large-scale polymorphism discovery in macaque G-protein coupled receptors
Published in
BMC Genomics, October 2013
DOI 10.1186/1471-2164-14-703
Pubmed ID
Authors

Dharmendra B Goswami, Lisa M Ogawa, Joshua M Ward, Gregory M Miller, Eric J Vallender

Abstract

G-protein coupled receptors (GPCRs) play an inordinately large role in human health. Variation in the genes that encode these receptors is associated with numerous disorders across the entire spectrum of disease. GPCRs also represent the single largest class of drug targets and associated pharmacogenetic effects are modulated, in part, by polymorphisms. Recently, non-human primate models have been developed focusing on naturally-occurring, functionally-parallel polymorphisms in candidate genes. This work aims to extend those studies broadly across the roughly 377 non-olfactory GPCRs. Initial efforts include resequencing 44 Indian-origin rhesus macaques (Macaca mulatta), 20 Chinese-origin rhesus macaques, and 32 cynomolgus macaques (M. fascicularis).

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 23 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 29%
Professor > Associate Professor 4 17%
Student > Bachelor 2 8%
Other 2 8%
Student > Ph. D. Student 2 8%
Other 3 13%
Unknown 4 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 25%
Agricultural and Biological Sciences 5 21%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Neuroscience 2 8%
Nursing and Health Professions 1 4%
Other 2 8%
Unknown 6 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2013.
All research outputs
#15,281,593
of 22,725,280 outputs
Outputs from BMC Genomics
#6,666
of 10,628 outputs
Outputs of similar age
#129,480
of 210,284 outputs
Outputs of similar age from BMC Genomics
#69
of 156 outputs
Altmetric has tracked 22,725,280 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,628 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,284 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 156 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.