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Jaccard index based similarity measure to compare transcription factor binding site models

Overview of attention for article published in Algorithms for Molecular Biology, September 2013
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Title
Jaccard index based similarity measure to compare transcription factor binding site models
Published in
Algorithms for Molecular Biology, September 2013
DOI 10.1186/1748-7188-8-23
Pubmed ID
Authors

Ilya E Vorontsov, Ivan V Kulakovskiy, Vsevolod J Makeev

Abstract

Positional weight matrix (PWM) remains the most popular for quantification of transcription factor (TF) binding. PWM supplied with a score threshold defines a set of putative transcription factor binding sites (TFBS), thus providing a TFBS model.TF binding DNA fragments obtained by different experimental methods usually give similar but not identical PWMs. This is also common for different TFs from the same structural family. Thus it is often necessary to measure the similarity between PWMs. The popular tools compare PWMs directly using matrix elements. Yet, for log-odds PWMs, negative elements do not contribute to the scores of highly scoring TFBS and thus may be different without affecting the sets of the best recognized binding sites. Moreover, the two TFBS sets recognized by a given pair of PWMs can be more or less different depending on the score thresholds.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 3 3%
Japan 1 1%
Unknown 86 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 22 24%
Student > Ph. D. Student 20 22%
Student > Bachelor 15 17%
Researcher 7 8%
Professor 6 7%
Other 10 11%
Unknown 10 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 27%
Computer Science 21 23%
Biochemistry, Genetics and Molecular Biology 16 18%
Engineering 5 6%
Decision Sciences 2 2%
Other 9 10%
Unknown 13 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2013.
All research outputs
#15,281,593
of 22,725,280 outputs
Outputs from Algorithms for Molecular Biology
#148
of 264 outputs
Outputs of similar age
#126,814
of 205,845 outputs
Outputs of similar age from Algorithms for Molecular Biology
#3
of 5 outputs
Altmetric has tracked 22,725,280 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 264 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 205,845 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.