Title |
Gene dysregulation by histone variant H2A.Z in bladder cancer
|
---|---|
Published in |
Epigenetics & Chromatin, October 2013
|
DOI | 10.1186/1756-8935-6-34 |
Pubmed ID | |
Authors |
Kyunghwan Kim, Vasu Punj, Jongkyu Choi, Kyu Heo, Jin-Man Kim, Peter W Laird, Woojin An |
Abstract |
The incorporation of histone variants into nucleosomes is one of the main strategies that the cell uses to regulate the structure and function of chromatin. Histone H2A.Z is an evolutionarily conserved histone H2A variant that is preferentially localized within nucleosomes at the transcriptional start site (TSS). H2A.Z reorganizes the local chromatin structure and recruits the transcriptional machinery for gene activation. High expression of H2A.Z has been reported in several types of cancers and is causally linked to genomic instability and tumorigenesis. However, it is not entirely clear how H2A.Z overexpression in cancer cells establishes aberrant chromatin states and promotes gene expression. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 43% |
Venezuela, Bolivarian Republic of | 1 | 14% |
United States | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 43% |
Scientists | 3 | 43% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 2 | 3% |
United States | 1 | 1% |
France | 1 | 1% |
Norway | 1 | 1% |
Unknown | 71 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 28% |
Researcher | 19 | 25% |
Student > Bachelor | 7 | 9% |
Student > Master | 6 | 8% |
Student > Doctoral Student | 5 | 7% |
Other | 8 | 11% |
Unknown | 10 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 41% |
Biochemistry, Genetics and Molecular Biology | 19 | 25% |
Chemistry | 11 | 14% |
Medicine and Dentistry | 2 | 3% |
Immunology and Microbiology | 1 | 1% |
Other | 3 | 4% |
Unknown | 9 | 12% |