The field should identify a few models in which key Alzheimer phenotypes are well replicated and characterize these models fully with regard to major targets and how they are affected by major biological and experimental variables (age, gender and housing)
2,545 followers
2,545 followers
2,545 followers
@Negin_Baba @ApitiusHofmann Challenges in translating preclinical studies to clinical trials include the inability of animal models to recapitulate the human disease, conduct & analysis of animal trials, & publication bias due to under-reporting of
2,545 followers
@JLLanciego There is no standard model or set protocol for testing investigational treatments in Alzheimer, and it is critical to tailor the choice of model, experimental plan, and outcome measures specifically for the therapy’s target or proposed mechanis