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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Allopurinol use and the risk of acute cardiovascular events in patients with gout and diabetes
|
|---|---|
| Published in |
BMC Cardiovascular Disorders, March 2017
|
| DOI | 10.1186/s12872-017-0513-6 |
| Pubmed ID | |
| Authors |
Jasvinder A. Singh, Rekha Ramachandaran, Shaohua Yu, Jeffrey R. Curtis |
| Abstract |
Few studies, if any, have examined cardiovascular outcomes in patients with diabetes and gout. Both diabetes and gout are risk factors for cardiovascular disease. The objective of this study was to examine the effect of allopurinol on the risk of incident acute cardiovascular events in patients with gout and diabetes. We used the 2007-2010 Multi-Payer Claims Database (MPCD) that linked health plan data from national commercial and governmental insurances, representing beneficiaries with United Healthcare, Medicare, or Medicaid coverage. In patients with gout and diabetes, we assessed the current allopurinol use, defined as a new filled prescription for allopurinol, as the main predictor of interest. Our outcome of interest was the occurrence of the first Incident hospitalized myocardial infarction (MI) or stroke (composite acute cardiovascular event), after which observations were censored. We employed multivariable-adjusted Cox proportional hazards models that simultaneously adjusted for patient demographics, cardiovascular risk factors and other medical comorbidities. We calculated hazard ratios [HR] (95% confidence intervals [CI]) for incident composite (MI or stroke) acute cardiovascular events. We performed sensitivity analyses that additionally adjusted for the presence of immune diseases and colchicine use, as potential confounders. There were 2,053,185 person days (5621.3 person years) of current allopurinol use and 1,671,583 person days (4576.5 person years) of prior allopurinol use. There were 158 incident MIs or strokes in current and 151 in prior allopurinol users, respectively. Compared to previous allopurinol users, current allopurinol users had significantly lower adjusted hazard of incident acute cardiovascular events (incident stroke or MI), with an HR of 0.67 (95% CI, 0.53, 0.84). Sensitivity analyses, additionally adjusted for immune diseases or colchicine use, confirmed this association. Current allopurinol use protected against the occurrence of acute cardiovascular events in patients with gout and diabetes. The underlying mechanisms for this potential cardio-protective effect of allopurinol need further exploration. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 38% |
| France | 2 | 13% |
| Canada | 1 | 6% |
| Singapore | 1 | 6% |
| Italy | 1 | 6% |
| India | 1 | 6% |
| Unknown | 4 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 56% |
| Practitioners (doctors, other healthcare professionals) | 4 | 25% |
| Scientists | 2 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 93 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 12% |
| Researcher | 10 | 11% |
| Student > Ph. D. Student | 10 | 11% |
| Other | 9 | 10% |
| Student > Bachelor | 8 | 9% |
| Other | 15 | 16% |
| Unknown | 30 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 45% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 8% |
| Engineering | 2 | 2% |
| Nursing and Health Professions | 2 | 2% |
| Agricultural and Biological Sciences | 2 | 2% |
| Other | 7 | 8% |
| Unknown | 31 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2019.
All research outputs
#3,741,795
of 25,728,855 outputs
Outputs from BMC Cardiovascular Disorders
#171
of 1,947 outputs
Outputs of similar age
#65,116
of 322,908 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#4
of 30 outputs
Altmetric has tracked 25,728,855 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,947 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,908 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.