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Wild-type but not mutant SOD1 transgenic astrocytes promote the efficient generation of motor neuron progenitors from mouse embryonic stem cells

Overview of attention for article published in BMC Neuroscience, October 2013
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Title
Wild-type but not mutant SOD1 transgenic astrocytes promote the efficient generation of motor neuron progenitors from mouse embryonic stem cells
Published in
BMC Neuroscience, October 2013
DOI 10.1186/1471-2202-14-126
Pubmed ID
Authors

Yiota A Christou, Kyoji Ohyama, Marysia Placzek, Peter N Monk, Pamela J Shaw

Abstract

The efficient derivation of mature (Hb9+) motor neurons from embryonic stem cells is a sought-after goal in the understanding, and potential treatment, of motor neuron diseases. Conditions that promote the robust generation of motor neuron progenitors from embryonic stem cells and that promote the survival of differentiated motor neurons ex vivo are likely, therefore, to be critical in future biological/therapeutic/screening approaches. Previous studies have shown that astrocytes have a protective effect on differentiated motor neurons (in vivo and ex vivo), but it remains unclear whether astrocytes also play a beneficial role in the support of motor neuron progenitors. Here we explore the effect of murine astrocyte-conditioned medium on monolayer cultures of mouse embryonic stem cell-derived motor neuron progenitors.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Turkey 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 19%
Researcher 8 19%
Student > Ph. D. Student 8 19%
Student > Bachelor 6 14%
Student > Doctoral Student 4 10%
Other 6 14%
Unknown 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 33%
Biochemistry, Genetics and Molecular Biology 8 19%
Medicine and Dentistry 8 19%
Neuroscience 3 7%
Psychology 2 5%
Other 3 7%
Unknown 4 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2014.
All research outputs
#17,700,887
of 22,727,570 outputs
Outputs from BMC Neuroscience
#813
of 1,241 outputs
Outputs of similar age
#151,852
of 211,883 outputs
Outputs of similar age from BMC Neuroscience
#22
of 48 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,241 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 211,883 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.