Title |
Initiation and continuation of randomized trials after the publication of a trial stopped early for benefit asking the same study question: STOPIT-3 study design
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Published in |
Trials, October 2013
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DOI | 10.1186/1745-6215-14-335 |
Pubmed ID | |
Authors |
Gabriela J Prutsky, Juan Pablo Domecq, Patricia J Erwin, Matthias Briel, Victor M Montori, Elie A Akl, Joerg J Meerpohl, Dirk Bassler, Stefan Schandelmaier, Stephen D Walter, Qi Zhou, Pablo Alonso Coello, Lorenzo Moja, Martin Walter, Kristian Thorlund, Paul Glasziou, Regina Kunz, Ignacio Ferreira-Gonzalez, Jason Busse, Xin Sun, Annette Kristiansen, Benjamin Kasenda, Osama Qasim-Agha, Gennaro Pagano, Hector Pardo-Hernandez, Gerard Urrutia, Mohammad Hassan Murad, Gordon Guyatt |
Abstract |
Randomized control trials (RCTs) stopped early for benefit (truncated RCTs) are increasingly common and, on average, overestimate the relative magnitude of benefit by approximately 30%. Investigators stop trials early when they consider it is no longer ethical to enroll patients in a control group. The goal of this systematic review is to determine how investigators of ongoing or planned RCTs respond to the publication of a truncated RCT addressing a similar question. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Canada | 1 | 2% |
Unknown | 41 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 23% |
Other | 5 | 12% |
Student > Ph. D. Student | 5 | 12% |
Professor | 5 | 12% |
Professor > Associate Professor | 3 | 7% |
Other | 8 | 19% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 24 | 56% |
Economics, Econometrics and Finance | 2 | 5% |
Unspecified | 1 | 2% |
Business, Management and Accounting | 1 | 2% |
Arts and Humanities | 1 | 2% |
Other | 4 | 9% |
Unknown | 10 | 23% |