Title |
A novel method to assess collagen architecture in skin
|
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Published in |
BMC Bioinformatics, August 2013
|
DOI | 10.1186/1471-2105-14-260 |
Pubmed ID | |
Authors |
Osman S Osman, Joanne L Selway, Parvathy E Harikumar, Claire J Stocker, Edward T Wargent, Michael A Cawthorne, Sabah Jassim, Kenneth Langlands |
Abstract |
Texture within biological specimens may reveal critical insights, while being very difficult to quantify. This is a particular problem in histological analysis. For example, cross-polar images of picrosirius stained skin reveal exquisite structure, allowing changes in the basketweave conformation of healthy collagen to be assessed. Existing techniques measure gross pathological changes, such as fibrosis, but are not sufficiently sensitive to detect more subtle and progressive pathological changes in the dermis, such as those seen in ageing. Moreover, screening methods for cutaneous therapeutics require accurate, unsupervised and high-throughput image analysis techniques. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 50% |
Japan | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 2 | 2% |
South Africa | 1 | 1% |
United Kingdom | 1 | 1% |
Iran, Islamic Republic of | 1 | 1% |
Belgium | 1 | 1% |
Unknown | 86 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 28% |
Researcher | 17 | 18% |
Student > Master | 12 | 13% |
Student > Bachelor | 8 | 9% |
Student > Doctoral Student | 4 | 4% |
Other | 14 | 15% |
Unknown | 11 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 22% |
Engineering | 15 | 16% |
Medicine and Dentistry | 12 | 13% |
Biochemistry, Genetics and Molecular Biology | 9 | 10% |
Materials Science | 4 | 4% |
Other | 16 | 17% |
Unknown | 16 | 17% |