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Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model

Overview of attention for article published in Cardiovascular Diabetology, June 2013
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Title
Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model
Published in
Cardiovascular Diabetology, June 2013
DOI 10.1186/1475-2840-12-89
Pubmed ID
Authors

Eduardo Morvan, Nathalia Edviges Alves Lima, Jacqueline Freire Machi, Cristiano Mostarda, Kátia De Angelis, Maria Cláudia Irigoyen, Rogério Brandão Wichi, Bruno Rodrigues, Laura Beatriz Mesiano Maifrino

Abstract

BACKGROUND: The increase in fructose consumption is paralleled by a higher incidence of metabolic syndrome, and consequently, cardiovascular disease mortality. We examined the effects of 8 weeks of low intensity exercise training (LET) on metabolic, hemodynamic, ventricular and vascular morphological changes induced by fructose drinking in male rats. METHODS: Male Wistar rats were divided into (n=8 each) control (C), sedentary fructose (F) and ET fructose (FT) groups. Fructose-drinking rats received D-fructose (100 g/l). FT rats were assigned to a treadmill training protocol at low intensity (30% of maximal running speed) during 1 h/day, 5 days/week for 8 weeks. Measurements of triglyceride concentrations, white adipose tissue (WAT) and glycemia were carried out together with insulin tolerance test to evaluate metabolic profile. Arterial pressure (AP) signals were directly recorded. Baroreflex sensitivity (BS) was evaluated by the tachycardic and bradycardic responses. Right atria, left ventricle (LV) and ascending aorta were prepared to morphoquantitative analysis. RESULTS: LET reduced WAT (-37.7%), triglyceride levels (-33%), systolic AP (-6%), heart weight/body weight (-20.5%), LV (-36%) and aortic (-76%) collagen fibers, aortic intima-media thickness and circumferential wall tension in FT when compared to F rats. Additionally, FT group presented improve of BS, numerical density of atrial natriuretic peptide granules (+42%) and LV capillaries (+25%), as well as the number of elastic lamellae in aorta compared with F group. CONCLUSIONS: Our data suggest that LET, a widely recommended practice, seems to be particularly effective for preventing metabolic, hemodynamic and morphological disorders triggered by MS.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Brazil 1 2%
Unknown 54 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 21%
Student > Postgraduate 6 11%
Student > Master 5 9%
Student > Bachelor 5 9%
Researcher 4 7%
Other 11 20%
Unknown 13 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 21%
Medicine and Dentistry 8 14%
Biochemistry, Genetics and Molecular Biology 6 11%
Nursing and Health Professions 6 11%
Sports and Recreations 6 11%
Other 4 7%
Unknown 14 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2013.
All research outputs
#18,351,676
of 22,727,570 outputs
Outputs from Cardiovascular Diabetology
#1,027
of 1,367 outputs
Outputs of similar age
#147,818
of 196,809 outputs
Outputs of similar age from Cardiovascular Diabetology
#5
of 8 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,367 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,809 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.