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Novel ω-Conotoxins from C. Catus Reverse Signs of Mouse Inflammatory Pain after Systemic Administration

Overview of attention for article published in Molecular Pain, January 2013
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Title
Novel ω-Conotoxins from C. Catus Reverse Signs of Mouse Inflammatory Pain after Systemic Administration
Published in
Molecular Pain, January 2013
DOI 10.1186/1744-8069-9-51
Pubmed ID
Authors

Mahsa Sadeghi, Swetha S Murali, Richard J Lewis, Paul F Alewood, Sarasa Mohammadi, MacDonald J Christie

Abstract

Antagonists of N-type voltage-gated calcium channels (VGCC), Ca(v)2.2, can manage severe chronic pain with intrathecal use and may be effective systemically. A series of novel ω-conotoxins that selectively inhibit N-type VGCCs was isolated from Conus catus. In the present study, the potency and reversibility of ω-conotoxins CVID, CVIE and CVIF to inhibit N-type calcium currents were investigated in mouse isolated dorsal root ganglion (DRG) neurons. The systemic potency of each ω-conotoxin to reverse signs of mouse chronic inflammatory pain was also compared.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 17%
Other 3 10%
Professor 3 10%
Student > Bachelor 2 7%
Researcher 2 7%
Other 4 14%
Unknown 10 34%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 21%
Biochemistry, Genetics and Molecular Biology 4 14%
Medicine and Dentistry 3 10%
Neuroscience 3 10%
Psychology 1 3%
Other 1 3%
Unknown 11 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2013.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Molecular Pain
#595
of 669 outputs
Outputs of similar age
#258,420
of 289,007 outputs
Outputs of similar age from Molecular Pain
#40
of 41 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,007 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.