Title |
Discovery and full genome characterization of two highly divergent simian immunodeficiency viruses infecting black-and-white colobus monkeys (Colobus guereza) in Kibale National Park, Uganda
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Published in |
Retrovirology, October 2013
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DOI | 10.1186/1742-4690-10-107 |
Pubmed ID | |
Authors |
Michael Lauck, William M Switzer, Samuel D Sibley, David Hyeroba, Alex Tumukunde, Geoffrey Weny, Bill Taylor, Anupama Shankar, Nelson Ting, Colin A Chapman, Thomas C Friedrich, Tony L Goldberg, David H O'Connor |
Abstract |
African non-human primates (NHPs) are natural hosts for simian immunodeficiency viruses (SIV), the zoonotic transmission of which led to the emergence of HIV-1 and HIV-2. However, our understanding of SIV diversity and evolution is limited by incomplete taxonomic and geographic sampling of NHPs, particularly in East Africa. In this study, we screened blood specimens from nine black-and-white colobus monkeys (Colobus guereza occidentalis) from Kibale National Park, Uganda, for novel SIVs using a combination of serology and "unbiased" deep-sequencing, a method that does not rely on genetic similarity to previously characterized viruses. |
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