Title |
CER1gene variations associated with bone mineral density, bone markers, and early menopause in postmenopausal women
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Published in |
Human Genomics, October 2013
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DOI | 10.1186/1479-7364-7-21 |
Pubmed ID | |
Authors |
Theodora Koromila, Panagiotis Georgoulias, Zoe Dailiana, Evangelia E Ntzani, Stavroula Samara, Chris Chassanidis, Vassiliki Aleporou-Marinou, Panagoula Kollia |
Abstract |
Osteoporosis has a multifactorial pathogenesis characterized by a combination of low bone mass and increased fragility. In our study, we focused on the effects of polymorphisms in CER1 and DKK1 genes, recently reported as important susceptibility genes for osteoporosis, on bone mineral density (BMD) and bone markers in osteoporotic women. Our objective was to evaluate the effect of CER1 and DKK1 variations in 607 postmenopausal women. The entire DKK1 gene sequence and five selected CER1 SNPs were amplified and resequenced to assess whether there is a correlation between these genes and BMD, early menopause, and bone turnover markers in osteoporotic patients. |
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United Kingdom | 1 | 100% |
Demographic breakdown
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 14% |
Researcher | 4 | 11% |
Student > Ph. D. Student | 4 | 11% |
Other | 3 | 9% |
Student > Bachelor | 3 | 9% |
Other | 5 | 14% |
Unknown | 11 | 31% |
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Medicine and Dentistry | 5 | 14% |
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Social Sciences | 1 | 3% |
Other | 1 | 3% |
Unknown | 12 | 34% |