Title |
Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors
|
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Published in |
Molecular Neurodegeneration, October 2013
|
DOI | 10.1186/1750-1326-8-41 |
Pubmed ID | |
Authors |
Karthikeyan Veeraraghavalu, Se Hoon Choi, Xiaoqiong Zhang, Sangram S Sisodia |
Abstract |
Alzheimer's disease (AD) is characterized by progressive memory loss and impaired cognitive function. Early-onset familial forms of the disease (FAD) are caused by inheritance of mutant genes encoding presenilin 1 (PS1) variants. We have demonstrated that prion promoter (PrP)-driven expression of human FAD-linked PS1 variants in mice leads to impairments in environmental enrichment (EE)-induced adult hippocampal neural progenitor cell (AHNPC) proliferation and neuronal differentiation, and have provided evidence that accessory cells in the hippocampal niche expressing PS1 variants may modulate AHNPC phenotypes, in vivo. While of significant interest, these latter studies relied on transgenic mice that express human PS1 variant transgenes ubiquitously and at high levels, and the consequences of wild type or mutant PS1 expressed under physiologically relevant levels on EE-mediated AHNPC phenotypes has not yet been tested. |
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Chile | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 2% |
Unknown | 48 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 16% |
Student > Ph. D. Student | 7 | 14% |
Professor | 5 | 10% |
Student > Bachelor | 5 | 10% |
Researcher | 4 | 8% |
Other | 12 | 24% |
Unknown | 8 | 16% |
Readers by discipline | Count | As % |
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Neuroscience | 8 | 16% |
Biochemistry, Genetics and Molecular Biology | 7 | 14% |
Agricultural and Biological Sciences | 7 | 14% |
Psychology | 4 | 8% |
Unspecified | 3 | 6% |
Other | 8 | 16% |
Unknown | 12 | 24% |