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Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders

Overview of attention for article published in Journal of Neurodevelopmental Disorders, August 2013
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2 X users
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1 Google+ user

Citations

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189 Mendeley
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Title
Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders
Published in
Journal of Neurodevelopmental Disorders, August 2013
DOI 10.1186/1866-1955-5-22
Pubmed ID
Authors

Yongjie Yang, Haruki Higashimori, Lydie Morel

Abstract

Recent studies have implicated potentially significant roles for astrocytes in the pathogenesis of neurodevelopmental disorders. Astrocytes undergo a dramatic maturation process following early differentiation from which typical morphology and important functions are acquired. Despite significant progress in understanding their early differentiation, very little is known about how astrocytes become functionally mature. In addition, whether functional maturation of astrocytes is disrupted in neurodevelopmental disorders and the consequences of this disruption remains essentially unknown. In this review, we discuss our perspectives about how astrocyte developmental maturation is regulated, and how disruption of the astrocyte functional maturation process, especially alterations in their ability to regulate glutamate homeostasis, may alter synaptic physiology and contribute to the pathogenesis of neurodevelopmental disorders.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 189 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Brazil 1 <1%
Unknown 186 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 56 30%
Researcher 26 14%
Student > Master 18 10%
Student > Bachelor 15 8%
Student > Doctoral Student 14 7%
Other 24 13%
Unknown 36 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 26%
Neuroscience 49 26%
Biochemistry, Genetics and Molecular Biology 20 11%
Medicine and Dentistry 14 7%
Unspecified 4 2%
Other 11 6%
Unknown 41 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2013.
All research outputs
#13,045,986
of 22,727,570 outputs
Outputs from Journal of Neurodevelopmental Disorders
#305
of 476 outputs
Outputs of similar age
#102,619
of 199,838 outputs
Outputs of similar age from Journal of Neurodevelopmental Disorders
#10
of 12 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 476 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,838 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.