Title |
Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders
|
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Published in |
Journal of Neurodevelopmental Disorders, August 2013
|
DOI | 10.1186/1866-1955-5-22 |
Pubmed ID | |
Authors |
Yongjie Yang, Haruki Higashimori, Lydie Morel |
Abstract |
Recent studies have implicated potentially significant roles for astrocytes in the pathogenesis of neurodevelopmental disorders. Astrocytes undergo a dramatic maturation process following early differentiation from which typical morphology and important functions are acquired. Despite significant progress in understanding their early differentiation, very little is known about how astrocytes become functionally mature. In addition, whether functional maturation of astrocytes is disrupted in neurodevelopmental disorders and the consequences of this disruption remains essentially unknown. In this review, we discuss our perspectives about how astrocyte developmental maturation is regulated, and how disruption of the astrocyte functional maturation process, especially alterations in their ability to regulate glutamate homeostasis, may alter synaptic physiology and contribute to the pathogenesis of neurodevelopmental disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Brazil | 1 | <1% |
Unknown | 186 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 56 | 30% |
Researcher | 26 | 14% |
Student > Master | 18 | 10% |
Student > Bachelor | 15 | 8% |
Student > Doctoral Student | 14 | 7% |
Other | 24 | 13% |
Unknown | 36 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 50 | 26% |
Neuroscience | 49 | 26% |
Biochemistry, Genetics and Molecular Biology | 20 | 11% |
Medicine and Dentistry | 14 | 7% |
Unspecified | 4 | 2% |
Other | 11 | 6% |
Unknown | 41 | 22% |