Title |
Central nervous system progression in advanced non–small cell lung cancer patients with EGFR mutations in response to first-line treatment with two EGFR-TKIs, gefitinib and erlotinib: a comparative study
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Published in |
BMC Cancer, April 2017
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DOI | 10.1186/s12885-017-3165-0 |
Pubmed ID | |
Authors |
Meng-Xia Li, Hao He, Zhi-Hua Ruan, Yu-Xi Zhu, Rong-Qing Li, Xiao He, Bao-Hua Lan, Zhi-Min Zhang, Guo-Dong Liu, Hua-Liang Xiao, Yan Wu, Bo Zhu, Ge Wang, Zhen-Zhou Yang |
Abstract |
Central nervous system (CNS) brain metastasis of advanced non-small cell lung cancer (NSCLC) patients confers a worse quality of life and prognosis. The efficacy comparison of two first-generation epidermal growth factor receptor (EGFR) inhibitors erlotinib or gefitinib as first-line treatment for CNS metastasis NSCLC patients with EGFR-sensitizing mutations is yet to be elucidated. A retrospective analysis was done on cerebral metastasis rate after erlotinib or gefitinib as first-line treatment for advanced NSCLC patients with EGFR-sensitizing mutations. Time to neurological progression (nTTP) and median progression-free survival (mPFS) were calculated. The study involved 279 patients (erlotinib group: 108, gefitinib group: 171). After a median follow-up of 22 months, 27 patients (25%) in the erlotinib group and 60 patients (35.1%) in the gefitinib group showed CNS progression. The HR of CNS progression for erlotinib versus gefitinib was 0.695 [95% confidence interval (CI), 0.406-1.190], suggesting a risk reduction of 30.5% although not achieving statistical significance. The 6-, 12- and 18-month cumulative CNS progression rates were 0.9, 3.7 and 12% for erlotinib compared with corresponding rates of 5.8, 9.4 and 17% for gefitinib (P = 0.181). However, for those patients with preexisting brain metastases prior to EGFR-TKI treatment, erlotinib as first line treatment significantly extended the median nTTP in comparison to gefitinib (30 months vs 15.8 months, p = 0.024). Our data show that nTTP can be effectively extended in preexisting brain metastases patients with EGFR-sensitizing mutations initially treated with erlotinib compared with gefitinib. If confirmed, our results indicate that erlotinib may play an important role in controlling CNS progression from EGFR mutation-positive NSCLC. |
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Portugal | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 19% |
Student > Ph. D. Student | 4 | 11% |
Student > Master | 4 | 11% |
Student > Bachelor | 3 | 8% |
Other | 3 | 8% |
Other | 7 | 19% |
Unknown | 8 | 22% |
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Medicine and Dentistry | 14 | 39% |
Nursing and Health Professions | 4 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Neuroscience | 2 | 6% |
Business, Management and Accounting | 1 | 3% |
Other | 5 | 14% |
Unknown | 8 | 22% |