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High dose vitamin D supplementation does not affect biochemical bone markers in multiple sclerosis – a randomized controlled trial

Overview of attention for article published in BMC Neurology, April 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

twitter
10 tweeters
facebook
2 Facebook pages

Citations

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14 Dimensions

Readers on

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87 Mendeley
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Title
High dose vitamin D supplementation does not affect biochemical bone markers in multiple sclerosis – a randomized controlled trial
Published in
BMC Neurology, April 2017
DOI 10.1186/s12883-017-0851-0
Pubmed ID
Authors

Trygve Holmøy, Jonas Christoffer Lindstrøm, Erik Fink Eriksen, Linn Hofsøy Steffensen, Margitta T. Kampman

Abstract

People with multiple sclerosis have high risk of osteoporosis and fractures. A poor vitamin D status is a risk factor for MS, and vitamin D supplementation has been recommended both to prevent MS progression and to maintain bone health. We assessed the effect of 20,000 IU vitamin D3 weekly compared to placebo on biochemical markers of bone metabolism in 68 persons with relapsing remitting multiple sclerosis. Serum levels of 25-hydroxyvitamin D more than doubled in the vitamin D group, and parathyroid hormone decreased in the vitamin D group compared to the placebo group at week 48 and week 96. There was however no effect on bone formation as measured by procollagen type I N propeptide (PINP), or on bone resorption as measured by C-terminal cross-linking telopeptide of type I collagen (CTX1). Neither PINP nor CTX1 predicted bone loss from baseline to week 96. These findings corroborate the previously reported lack of effect of weekly high dose vitamin D supplementation on bone mass density in the same patients, and suggest that such vitamin D supplementation does not prevent bone loss in persons with MS who are not vitamin D deficient. The trial was registered at ClinicalTrials.gov on April 4 2008, registration number NCT00785473 .

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 87 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 18 21%
Other 8 9%
Student > Postgraduate 8 9%
Student > Master 8 9%
Student > Doctoral Student 5 6%
Other 17 20%
Unknown 23 26%
Readers by discipline Count As %
Medicine and Dentistry 23 26%
Nursing and Health Professions 13 15%
Agricultural and Biological Sciences 6 7%
Biochemistry, Genetics and Molecular Biology 4 5%
Neuroscience 4 5%
Other 4 5%
Unknown 33 38%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2017.
All research outputs
#1,839,544
of 11,626,228 outputs
Outputs from BMC Neurology
#258
of 1,333 outputs
Outputs of similar age
#62,944
of 265,161 outputs
Outputs of similar age from BMC Neurology
#8
of 27 outputs
Altmetric has tracked 11,626,228 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,333 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,161 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.