Title |
Neuroprotective effects of donepezil against cholinergic depletion
|
---|---|
Published in |
Alzheimer's Research & Therapy, October 2013
|
DOI | 10.1186/alzrt215 |
Pubmed ID | |
Authors |
Debora Cutuli, Paola De Bartolo, Paola Caporali, Anna Maria Tartaglione, Diego Oddi, Francesca Romana D’Amato, Annalisa Nobili, Marcello D’Amelio, Laura Petrosini |
Abstract |
Intraparenchymal injections of the immunotoxin 192-IgG-saporin into medial septum and nucleus basalis magnocellularis causes a selective depletion of basal forebrain cholinergic neurons. Thus, it represents a valid model to mimic a key component of the cognitive deficits associated with aging and dementia. Here we administered donepezil, a potent acetylcholinesterase inhibitor developed for treating Alzheimer's disease, 15 days before 192-IgG-saporin injection, and thus we examined donepezil effects on neurodegeneration and cognitive deficits. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 2% |
Unknown | 56 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 18% |
Student > Bachelor | 7 | 12% |
Researcher | 6 | 11% |
Professor | 5 | 9% |
Student > Master | 5 | 9% |
Other | 12 | 21% |
Unknown | 12 | 21% |
Readers by discipline | Count | As % |
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Neuroscience | 9 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 14% |
Psychology | 5 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 9 | 16% |
Unknown | 13 | 23% |