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Neuroprotective effects of donepezil against cholinergic depletion

Overview of attention for article published in Alzheimer's Research & Therapy, October 2013
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2 X users
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Citations

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42 Dimensions

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57 Mendeley
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Title
Neuroprotective effects of donepezil against cholinergic depletion
Published in
Alzheimer's Research & Therapy, October 2013
DOI 10.1186/alzrt215
Pubmed ID
Authors

Debora Cutuli, Paola De Bartolo, Paola Caporali, Anna Maria Tartaglione, Diego Oddi, Francesca Romana D’Amato, Annalisa Nobili, Marcello D’Amelio, Laura Petrosini

Abstract

Intraparenchymal injections of the immunotoxin 192-IgG-saporin into medial septum and nucleus basalis magnocellularis causes a selective depletion of basal forebrain cholinergic neurons. Thus, it represents a valid model to mimic a key component of the cognitive deficits associated with aging and dementia. Here we administered donepezil, a potent acetylcholinesterase inhibitor developed for treating Alzheimer's disease, 15 days before 192-IgG-saporin injection, and thus we examined donepezil effects on neurodegeneration and cognitive deficits.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 18%
Student > Bachelor 7 12%
Researcher 6 11%
Professor 5 9%
Student > Master 5 9%
Other 12 21%
Unknown 12 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 18%
Neuroscience 9 16%
Pharmacology, Toxicology and Pharmaceutical Science 8 14%
Psychology 5 9%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 9 16%
Unknown 13 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2013.
All research outputs
#15,983,785
of 25,374,917 outputs
Outputs from Alzheimer's Research & Therapy
#1,318
of 1,465 outputs
Outputs of similar age
#128,362
of 224,529 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#15
of 19 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,465 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,529 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.