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HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T cell-only mouse (TOM) model

Overview of attention for article published in Retrovirology: Research & Treatment, October 2013
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1 tweeter

Citations

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50 Dimensions

Readers on

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47 Mendeley
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Title
HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T cell-only mouse (TOM) model
Published in
Retrovirology: Research & Treatment, October 2013
DOI 10.1186/1742-4690-10-121
Pubmed ID
Authors

Jenna B Honeycutt, Angela Wahl, Nancie Archin, Shailesh Choudhary, David Margolis, J Victor Garcia

Abstract

The major targets of HIV infection in humans are CD4⁺ T cells. CD4⁺ T cell depletion is a hallmark of AIDS. Previously, the SCID-hu thy/liv model was used to study the effect of HIV on thymopoeisis in vivo. However, these mice did not develop high levels of peripheral T cell reconstitution and required invasive surgery for infection and analysis. Here, we describe a novel variant of this model in which thy/liv implantation results in systemic reconstitution with human T cells in the absence of any other human hematopoietic lineages.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 26%
Student > Bachelor 8 17%
Student > Ph. D. Student 6 13%
Professor > Associate Professor 5 11%
Student > Master 4 9%
Other 7 15%
Unknown 5 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 43%
Medicine and Dentistry 7 15%
Immunology and Microbiology 7 15%
Biochemistry, Genetics and Molecular Biology 3 6%
Veterinary Science and Veterinary Medicine 1 2%
Other 3 6%
Unknown 6 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2013.
All research outputs
#3,563,054
of 4,507,509 outputs
Outputs from Retrovirology: Research & Treatment
#510
of 634 outputs
Outputs of similar age
#80,943
of 101,916 outputs
Outputs of similar age from Retrovirology: Research & Treatment
#43
of 52 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one is in the 3rd percentile – i.e., 3% of other outputs scored the same or lower than it.
So far Altmetric has tracked 634 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 101,916 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.