Title |
Studies of association of AGPAT6variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes
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Published in |
BMC Medical Genomics, October 2013
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DOI | 10.1186/1471-2350-14-113 |
Pubmed ID | |
Authors |
Lena Sønder Snogdal, Niels Grarup, Karina Banasik, Mette Wod, Torben Jørgensen, Daniel R Witte, Torsten Lauritzen, Aneta A Nielsen, Ivan Brandslund, Cramer Christensen, Oluf Pedersen, Knud Yderstræde, Henning Beck-Nielsen, Jan Erik Henriksen, Torben Hansen, Kurt Højlund |
Abstract |
Type 2 diabetes, obesity and insulin resistance are characterized by hypertriglyceridemia and ectopic accumulation of lipids in liver and skeletal muscle. AGPAT6 encodes a novel glycerol-3 phosphate acyltransferase, GPAT4, which catalyzes the first step in the de novo triglyceride synthesis. AGPAT6-deficient mice show lower weight and resistance to diet- and genetically induced obesity. Here, we examined whether common or low-frequency variants in AGPAT6 associate with type 2 diabetes or related metabolic traits in a Danish population. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 15% |
Researcher | 3 | 11% |
Professor > Associate Professor | 3 | 11% |
Student > Master | 3 | 11% |
Student > Ph. D. Student | 2 | 7% |
Other | 6 | 22% |
Unknown | 6 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 33% |
Agricultural and Biological Sciences | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Unspecified | 1 | 4% |
Psychology | 1 | 4% |
Other | 3 | 11% |
Unknown | 8 | 30% |