Title |
Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing
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Published in |
Molecular Brain, April 2017
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DOI | 10.1186/s13041-017-0291-1 |
Pubmed ID | |
Authors |
Richard T. O’Neil, Xiaojing Wang, Michael V. Morabito, Ronald B. Emeson |
Abstract |
A-to-I RNA editing is an important process for generating molecular diversity in the brain through modification of transcripts encoding several proteins important for neuronal signaling. We investigated the relationships between the extent of editing at multiple substrate transcripts (5HT2C, MGLUR4, CADPS, GLUR2, GLUR4, and GABRA3) in brain tissue obtained from adult humans and rhesus macaques. Several patterns emerged from these studies revealing conservation of editing across primate species. Additionally, variability in the human population allows us to make novel inferences about the co-regulation of editing at different editing sites and even across different brain regions. |
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Unknown | 2 | 100% |
Demographic breakdown
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
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Luxembourg | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
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Student > Bachelor | 3 | 14% |
Researcher | 3 | 14% |
Student > Doctoral Student | 2 | 10% |
Student > Master | 2 | 10% |
Other | 4 | 19% |
Unknown | 2 | 10% |
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Biochemistry, Genetics and Molecular Biology | 4 | 19% |
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Chemistry | 1 | 5% |
Other | 0 | 0% |
Unknown | 2 | 10% |