Title |
Bayesian model selection validates a biokinetic model for zirconium processing in humans
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Published in |
BMC Systems Biology, August 2012
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DOI | 10.1186/1752-0509-6-95 |
Pubmed ID | |
Authors |
Daniel Schmidl, Sabine Hug, Wei Bo Li, Matthias B Greiter, Fabian J Theis |
Abstract |
In radiation protection, biokinetic models for zirconium processing are of crucial importance in dose estimation and further risk analysis for humans exposed to this radioactive substance. They provide limiting values of detrimental effects and build the basis for applications in internal dosimetry, the prediction for radioactive zirconium retention in various organs as well as retrospective dosimetry. Multi-compartmental models are the tool of choice for simulating the processing of zirconium. Although easily interpretable, determining the exact compartment structure and interaction mechanisms is generally daunting. In the context of observing the dynamics of multiple compartments, Bayesian methods provide efficient tools for model inference and selection. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 4% |
Unknown | 26 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 30% |
Researcher | 4 | 15% |
Student > Master | 4 | 15% |
Lecturer | 2 | 7% |
Student > Postgraduate | 2 | 7% |
Other | 3 | 11% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 4 | 15% |
Computer Science | 3 | 11% |
Mathematics | 3 | 11% |
Environmental Science | 3 | 11% |
Social Sciences | 2 | 7% |
Other | 8 | 30% |
Unknown | 4 | 15% |