Title |
Salinomycin increases chemosensitivity to the effects of doxorubicin in soft tissue sarcomas
|
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Published in |
BMC Cancer, October 2013
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DOI | 10.1186/1471-2407-13-490 |
Pubmed ID | |
Authors |
Sven-T Liffers, Daniel J Tilkorn, Ingo Stricker, Christoph Günter Junge, Sammy Al-Benna, Markus Vogt, Berlinda Verdoodt, Hans-U Steinau, Andrea Tannapfel, Iris Tischoff, Alireza Mirmohammadsadegh |
Abstract |
Chemotherapy for soft tissue sarcomas remains unsatisfactory due to their low chemosensitivity. Even the first line chemotherapeutic agent doxorubicin only yields a response rate of 18-29%. The antibiotic salinomycin, a potassium ionophore, has recently been shown to be a potent compound to deplete chemoresistant cells like cancer stem like cells (CSC) in adenocarcinomas. Here, we evaluated the effect of salinomycin on sarcoma cell lines, whereby salinomycin mono- and combination treatment with doxorubicin regimens were analyzed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 43% |
United Kingdom | 1 | 14% |
Ireland | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 31% |
Student > Bachelor | 5 | 17% |
Student > Master | 4 | 14% |
Student > Doctoral Student | 3 | 10% |
Professor | 2 | 7% |
Other | 4 | 14% |
Unknown | 2 | 7% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 10 | 34% |
Medicine and Dentistry | 9 | 31% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Unspecified | 2 | 7% |
Engineering | 2 | 7% |
Other | 0 | 0% |
Unknown | 4 | 14% |